Document Detail


Predicting and monitoring response to chemotherapy by 1,3-bis(2-chloroethyl)-1-nitrosourea in subcutaneously implanted 9L glioma using the apparent diffusion coefficient of water and 23Na MRI.
MedLine Citation:
PMID:  16758478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine the effects of the alkylating anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on (23)Na MRI and the water apparent diffusion coefficient (ADC) in subcutaneously- (sc-) implanted 9L glioma in rats. MATERIALS AND METHODS: (23)Na MRI and (1)H water ADC measurements were performed on sham-treated control (N = 6) and BCNU-treated (N = 15) Fisher rats one day before BCNU injection and then one, three, and five days after BCNU injection. RESULTS: The BCNU-treated tumors were divided into BCNU-responsive (R(BCNU)) and BCNU-nonresponsive (NR(BCNU)) groups depending on the tumor volume changes that occurred after therapy. The pretreatment (23)Na MRI signal intensity (SI) and water ADC values were higher in R(BCNU) tumors compared to NR(BCNU) tumors. (23)Na MRI SI and water ADC increased with tumor growth in control and NR(BCNU) groups, but these changes were interrupted by BCNU therapy in R(BCNU) group. CONCLUSION: (23)Na MRI and water ADC measurements may be useful for predicting and monitoring response to chemotherapy in some tumors. However, the changes that occurred in (23)Na MRI SI and water ADC in sc-implanted 9L tumors are in contrast to previously published results for BCNU therapy of orthotopic 9L tumors. This may have important implications for monitoring therapy response in tumors.
Authors:
Andriy M Babsky; S K Hekmatyar; Hong Zhang; James L Solomon; Navin Bansal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  24     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-26     Completed Date:  2006-11-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Affiliation:
Indiana Center for Excellence in Biomedical Imaging, Department of Radiology, Indiana University, Indianapolis, Indiana, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Alkylating / pharmacology*
Carmustine / pharmacology*
Cell Line, Tumor
Glioma / drug therapy*
Magnetic Resonance Imaging / methods
Nitrosourea Compounds / pharmacology
Rats
Sodium / metabolism
Sodium Radioisotopes / pharmacology*
Time Factors
Treatment Outcome
Water / chemistry
Grant Support
ID/Acronym/Agency:
CA84434/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 0/Nitrosourea Compounds; 0/Sodium Radioisotopes; 154-93-8/Carmustine; 7440-23-5/Sodium; 7732-18-5/Water

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