| Predicting and managing the risk of pulmonary haemorrhage in patients with NSCLC treated with bevacizumab: a consensus report from a panel of experts. | |
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MedLine Citation:
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PMID: 22056855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. Severe pulmonary haemorrhage (PH) is a rare but serious potential adverse event associated with bevacizumab therapy for advanced non-squamous non-small-cell lung cancer (NSCLC). METHODS: A panel of expert oncologists, pulmonologists and radiologists reviewed the available data to identify predictive factors for PH in order to help guide physicians using bevacizumab in patients with NSCLC. RESULTS: Patients with NSCLC are at an increased risk of PH owing to the underlying disease process. Patients with squamous histology and/or a history of grade ≥ 2 haemoptysis (≥ 2.5 ml per event) should not receive bevacizumab. No clinical or radiological features (including cavitation and central tumour location) reliably predict severe PH in bevacizumab-treated patients. Major blood vessel infiltration and bronchial vessel infiltration, encasement and abutting may predict PH; however, standardised radiological criteria for defining infiltration have not been established. Eligibility for bevacizumab is not affected by patient age, performance status or anticoagulation or antiplatelet therapy. CONCLUSIONS: An individualised risk-benefit assessment should be undertaken in all patients with NSCLC in whom bevacizumab is being considered. Further research is required to elucidate the mechanisms underlying PH and the clinical risk factors. |
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Authors:
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M Reck; F Barlesi; L Crinò; C I Henschke; D Isla; S Stiebeler; D R Spigel |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-11-04 |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 23 ISSN: 1569-8041 ISO Abbreviation: Ann. Oncol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-25 Completed Date: 2012-09-07 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
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Languages: eng Pagination: 1111-20 Citation Subset: IM |
Affiliation:
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Department of Thoracic Oncology, Hospital Grosshansdorf, Grosshansdorf, Germany. dr.martin.reck@web.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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adverse effects,
therapeutic use Antibodies, Monoclonal, Humanized / adverse effects*, therapeutic use Carcinoma, Non-Small-Cell Lung / complications, diagnosis, drug therapy* Consensus Expert Testimony Forecasting / methods Hemorrhage / chemically induced, diagnosis*, etiology, therapy* Humans Lung Diseases / chemically induced, diagnosis*, etiology, therapy* Lung Neoplasms / complications, diagnosis, drug therapy* Prognosis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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