| Predicting long-term cognitive outcome with new regression models in donepezil-treated Alzheimer patients in a naturalistic setting. | |
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MedLine Citation:
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PMID: 18769065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To build and analyze regression models predicting (1) the long-term cognitive outcome in donepezil-treated patients with Alzheimer's disease, and (2) the short-term (6 months) cognitive impact of treatment depending on cognitive severity at baseline. METHODS: The Swedish Alzheimer Treatment Study (SATS) is an open-label, non-randomized, 3-year, multicentre study in a routine clinical setting. A total of 435 patients, mostly in the mild and moderate stages of Alzheimer's disease, received the cholinesterase inhibitor donepezil. They were assessed with the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) at baseline and every 6 months for a total period of 3 years. Regression models were fitted from the actual scores at different intervals for the prediction of the cognitive outcome. RESULTS: The ADAS-cog and MMSE scores during the 3-year treatment period could be predicted with a high degree of explanation using regression models (p < 0.001). Moreover, there was a significant relation between the mean cognitive change after 6 months of treatment and the baseline scores on MMSE (p < 0.01) and ADAS-cog (p < 0.001), respectively. CONCLUSION: Statistical models can be used to predict cognitive outcome in donepezil-treated cohorts of AD patients. These models can be clinically valuable, for example when assessing the efficacy of new therapies when added to cholinesterase inhibitor treatment. |
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Authors:
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Carina Wattmo; Oskar Hansson; Asa K Wallin; Elisabet Londos; Lennart Minthon |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study Date: 2008-09-04 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 26 ISSN: 1421-9824 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-01-08 Revised Date: 2009-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 203-11 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden. carina.wattmo@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / drug therapy*, physiopathology Cognition Disorders / drug therapy*, physiopathology Female Humans Indans / administration & dosage* Longitudinal Studies Male Middle Aged Models, Statistical* Nootropic Agents / administration & dosage* Patient Dropouts Piperidines / administration & dosage* Predictive Value of Tests Psychiatric Status Rating Scales Regression Analysis Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil |
| Comments/Corrections | |
Comment In:
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Nat Clin Pract Neurol. 2009 Mar;5(3):128-9
[PMID:
19190589
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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