Document Detail

Predicting long-term cognitive outcome with new regression models in donepezil-treated Alzheimer patients in a naturalistic setting.
MedLine Citation:
PMID:  18769065     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To build and analyze regression models predicting (1) the long-term cognitive outcome in donepezil-treated patients with Alzheimer's disease, and (2) the short-term (6 months) cognitive impact of treatment depending on cognitive severity at baseline. METHODS: The Swedish Alzheimer Treatment Study (SATS) is an open-label, non-randomized, 3-year, multicentre study in a routine clinical setting. A total of 435 patients, mostly in the mild and moderate stages of Alzheimer's disease, received the cholinesterase inhibitor donepezil. They were assessed with the Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) at baseline and every 6 months for a total period of 3 years. Regression models were fitted from the actual scores at different intervals for the prediction of the cognitive outcome. RESULTS: The ADAS-cog and MMSE scores during the 3-year treatment period could be predicted with a high degree of explanation using regression models (p < 0.001). Moreover, there was a significant relation between the mean cognitive change after 6 months of treatment and the baseline scores on MMSE (p < 0.01) and ADAS-cog (p < 0.001), respectively. CONCLUSION: Statistical models can be used to predict cognitive outcome in donepezil-treated cohorts of AD patients. These models can be clinically valuable, for example when assessing the efficacy of new therapies when added to cholinesterase inhibitor treatment.
Carina Wattmo; Oskar Hansson; Asa K Wallin; Elisabet Londos; Lennart Minthon
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study     Date:  2008-09-04
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  26     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-08     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  203-11     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / drug therapy*,  physiopathology
Cognition Disorders / drug therapy*,  physiopathology
Indans / administration & dosage*
Longitudinal Studies
Middle Aged
Models, Statistical*
Nootropic Agents / administration & dosage*
Patient Dropouts
Piperidines / administration & dosage*
Predictive Value of Tests
Psychiatric Status Rating Scales
Regression Analysis
Severity of Illness Index
Reg. No./Substance:
0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil
Comment In:
Nat Clin Pract Neurol. 2009 Mar;5(3):128-9   [PMID:  19190589 ]

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