| Predicting the histology of renal masses using preoperative Doppler ultrasonography. | |
| | |
MedLine Citation:
|
PMID: 17161999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Traditional imaging techniques cannot differentiate among benign, indolent and malignant renal neoplasms. Since conventional clear cell carcinomas are highly vascular, we used preoperative color and/or power Doppler ultrasonography to evaluate the association between vascular flow in a renal mass and surgical pathology. MATERIALS AND METHODS: Nephrectomies performed at our institution between January 2001 and December 2004 were retrospectively evaluated. Any detection of flow in the renal mass on color Doppler ultrasonography was defined as vascular flow. A prospective validation study was then performed from January 2005 to October 2005 and a nomogram was constructed to predict clear cell histology. RESULTS: Of 299 renal lesions in the retrospective cohort 210 (70%) had evidence of vascular flow, including 156 of 169 conventional clear cell carcinomas (92%) (p <0.0001). On logistic regression analysis vascular flow was associated with conventional clear cell histology (OR 16.9, 95% CI 8.7-32.8; p <0.0001). This finding was validated prospectively in 97 patients. Vascular flow was detected in 54 of 65 renal masses (83%) with conventional clear cell histology (p <0.0001), which was associated with an OR of 10.8 (95% CI 4.0-29.0; p <0.0001). A nomogram incorporating vascular flow along with clinical variables (clinical size, patient sex and age) to predict conventional clear cell histology was constructed on the retrospective cohort and validated on the prospective data set (concordance index 0.82 and 0.76, respectively). CONCLUSIONS: Vascular flow detected by color Doppler ultrasonography is strongly associated with conventional clear cell histology. A nomogram incorporating vascular flow on color Doppler ultrasonography and clinical parameters may aid in the preoperative characterization of renal lesions. |
| | |
Authors:
|
Ganesh V Raj; Ariadne M Bach; Alexia Iasonos; Ruslan Korets; Jeffrey Blitstein; Lucy Hann; Paul Russo |
Related Documents
:
|
16613309 - Indications of inflammation visualized by ultrasound in osteoarthritis of the knee. 3396179 - Evaluation of nonradioactive, colored microspheres for measurement of regional myocardi... 9120989 - Microvascular blood flow is altered after repair of testicular torsion in the rat. 17561969 - Diagnosis of rectal varices via color doppler ultrasonography. 12094169 - Use of pulse wave and color flow doppler echocardiography in mouse models of human dise... 2047049 - The antenatal diagnosis of congenital heart disease using fetal echocardiography: is co... 18243259 - Detection of hiv antigen and cdna among antibody-negative blood samples in nigeria. 2162989 - Blood ammonia concentration in mice: normal reference values and changes during growth. 20620699 - Cyclic and radial variation of the echogenicity of blood in human carotid arteries obse... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of urology Volume: 177 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 2007 Jan |
Date Detail:
|
Created Date: 2006-12-12 Completed Date: 2007-01-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 53-8 Citation Subset: AIM; IM |
Affiliation:
|
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Renal Cell / pathology*, surgery, ultrasonography* Female Humans Kidney Neoplasms / pathology*, surgery, ultrasonography* Male Middle Aged Predictive Value of Tests Preoperative Care Prospective Studies Retrospective Studies Ultrasonography, Doppler* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Uroscopy by Hippocrates and Theophilus: prognosis versus diagnosis.
Next Document: Impact of tumor size on the predictive ability of the pT3a primary tumor classification for renal ce...