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Predicting growth response among Egyptian prepubertal idiopathic isolated growth hormone deficient children.
MedLine Citation:
PMID:  23337051     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To determine the predictors of growth response to growth hormone treatment in a group of isolated idiopathic growth hormone (GH). Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year and up to 6 years. Multiple linear regressions were performed to identify predictors of growth response to rhGH in the first 4 years of treatment. Results: In the first year, three significant predictors of growth were identified: GH peak [ln (ug/L)], age of onset of therapy and target height-height SDS. In the second and third years of therapy, growth velocity (GV) was both significantly and positively correlated to the GV (cm/year) of the previous year. Conclusion: Prediction models offer a valuable tool for individualization and assuring adherence to rhGH and thus a cost effective treatment, which is the ultimate goal of GH therapy.
Authors:
Nermin Salah; Soha M Abd El Dayem; Lobna Fawaz; Marwa Ibrahim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  -     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
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