| Predicting growth response among Egyptian prepubertal idiopathic isolated growth hormone deficient children. | |
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MedLine Citation:
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PMID: 23337051 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To determine the predictors of growth response to growth hormone treatment in a group of isolated idiopathic growth hormone (GH). Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year and up to 6 years. Multiple linear regressions were performed to identify predictors of growth response to rhGH in the first 4 years of treatment. Results: In the first year, three significant predictors of growth were identified: GH peak [ln (ug/L)], age of onset of therapy and target height-height SDS. In the second and third years of therapy, growth velocity (GV) was both significantly and positively correlated to the GV (cm/year) of the previous year. Conclusion: Prediction models offer a valuable tool for individualization and assuring adherence to rhGH and thus a cost effective treatment, which is the ultimate goal of GH therapy. |
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Authors:
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Nermin Salah; Soha M Abd El Dayem; Lobna Fawaz; Marwa Ibrahim |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: - ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: 1-9 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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