Document Detail


Predicting concordance of biochemical lung maturity in the preterm twin gestation.
MedLine Citation:
PMID:  12422910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To propose a strategy for lung maturity amniocentesis in diamnionic twin gestations by exploiting indicators of concordance of lung maturity status. METHODS: Amniotic fluid from 92 diamnionic twin gestations was assayed for lung maturity by standard methodology. The rates of concordance of lung maturity status between twins were calculated after stratification by gestational age, chorionicity, gender and weight discordance. RESULTS: At the extremes of gestational age (28, 29, 36 and 37 weeks), twins are 100% concordant in lung status; for twins of 33-35.9 gestational weeks, lung concordance is significantly lower at 0.91 (p = 0.02); for 30-32.9 weeks, a rate of 0.52 is even lower (p = 0.001). Same-gender twin pairs of 33-35.9 weeks and twin pairs with estimated fetal weight discordance exceeding 20% or less than 10% were uniformly concordant in their lung maturity. CONCLUSION: Non-selective single amniocentesis may be performed if the gestational age is greater than 35.9 weeks. Double amniocentesis should be performed in the following: twins of 30-32.9 gestational weeks and twins of 33-35.9 weeks unless the twin pair is gender-concordant, or calculated fetal weight discordance is less than 10% or greater than 20%.
Authors:
M W Mackenzie
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  12     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-11-08     Completed Date:  2003-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-8     Citation Subset:  IM    
Affiliation:
Harvard Medical School, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Amniocentesis / standards*
Amniotic Fluid / metabolism*
Female
Fetal Organ Maturity*
Gestational Age
Humans
Lung / embryology*
Male
Predictive Value of Tests
Pregnancy
Twins*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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