Document Detail

Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis.
MedLine Citation:
PMID:  16550189     Owner:  NLM     Status:  MEDLINE    
We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.
Stephane Decramer; Stefan Wittke; Harald Mischak; Petra Zürbig; Michael Walden; François Bouissou; Jean-Loup Bascands; Joost P Schanstra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-19
Journal Detail:
Title:  Nature medicine     Volume:  12     ISSN:  1078-8956     ISO Abbreviation:  Nat. Med.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-06     Completed Date:  2006-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-400     Citation Subset:  IM    
Inserm, U388, 1 Avenue Jean Poulhes, F-31432 Toulouse, France.
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MeSH Terms
Biological Markers / urine*
Case-Control Studies
Double-Blind Method
Infant, Newborn
Kidney Pelvis / pathology*
Mass Spectrometry
Prospective Studies
Proteome / analysis*
Reference Standards
Reproducibility of Results
Severity of Illness Index
Specimen Handling
Time Factors
Ureteral Obstruction / congenital*,  diagnosis*,  metabolism,  pathology,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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