| Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. | |
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MedLine Citation:
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PMID: 16550189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction. |
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Authors:
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Stephane Decramer; Stefan Wittke; Harald Mischak; Petra Zürbig; Michael Walden; François Bouissou; Jean-Loup Bascands; Joost P Schanstra |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-19 |
Journal Detail:
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Title: Nature medicine Volume: 12 ISSN: 1078-8956 ISO Abbreviation: Nat. Med. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-06 Completed Date: 2006-06-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502015 Medline TA: Nat Med Country: United States |
Other Details:
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Languages: eng Pagination: 398-400 Citation Subset: IM |
Affiliation:
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Inserm, U388, 1 Avenue Jean Poulhes, F-31432 Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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urine* Case-Control Studies Double-Blind Method Female Humans Infant Infant, Newborn Kidney Pelvis / pathology* Male Mass Spectrometry Prognosis Prospective Studies Proteome / analysis* Reference Standards Reproducibility of Results Severity of Illness Index Specimen Handling Time Factors Ureteral Obstruction / congenital*, diagnosis*, metabolism, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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