| Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody. | |
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MedLine Citation:
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PMID: 22401638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a humanized monoclonal antibody (mAb) having high affinity and specificity for cocaine in animal models are reviewed. The mAb reduced the concentration of cocaine in the brain of mice after intravenous injection of cocaine. In addition, the mAb increased the concentration of cocaine required to reinstate cocaine self-administration. These effects may predict clinical efficacy of a passive immunotherapy for reducing the probability of cocaine-induced relapse. However, in the presence of the mAb, once cocaine self-administration was reinstated, the consumption rate of cocaine was increased. This effect is hypothesized to result from a pharmacokinetic/pharmacodynamic interaction. A humanized mAb should minimize adverse events related to the immunogenicity of the mAb protein, and the specificity for cocaine should avoid adverse events related to interactions with physiologically relevant endogenous proteins. |
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Authors:
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Andrew B Norman; William J Ball |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Immunotherapy Volume: 4 ISSN: 1750-7448 ISO Abbreviation: Immunotherapy Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-09 Completed Date: 2012-07-03 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 101485158 Medline TA: Immunotherapy Country: England |
Other Details:
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Languages: eng Pagination: 335-43 Citation Subset: IM |
Affiliation:
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Department of Pharmacology & Cell Biophysics and Department of Psychiatry & Behavioral Neuroscience, College of Medicine, University of Cincinnati, Cincinnati, OH 45237-0506, USA. andrew.norman@uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local*
/
adverse effects,
antagonists & inhibitors,
immunology,
pharmacokinetics Animals Antibodies, Monoclonal, Humanized* / adverse effects, immunology, pharmacokinetics, therapeutic use Brain / immunology, metabolism Cocaine* / adverse effects, antagonists & inhibitors, immunology, pharmacokinetics Cocaine-Related Disorders / immunology, metabolism, therapy* Disease Models, Animal Humans Immunization, Passive* Mice |
| Grant Support | |
ID/Acronym/Agency:
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DP1 DA031386-02/DA/NIDA NIH HHS; DP1DA031386/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Antibodies, Monoclonal, Humanized; 50-36-2/Cocaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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