| Predicting the clinical behavior of ovarian cancer from gene expression profiles. | |
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MedLine Citation:
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PMID: 16515583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether prognostic information is reflected in the expression patterns of ovarian carcinoma samples. RNA obtained from seven FIGO stage I without recurrence, seven platin-sensitive advanced-stage (III or IV), and six platin-resistant advanced-stage ovarian tumors was hybridized on a complementary DNA microarray with 21,372 spotted clones. The results revealed that a considerable number of genes exhibit nonaccidental differential expression between the different tumor classes. Principal component analysis reflected the differences between the three tumor classes and their order of transition. Using a leave-one-out approach together with least squares support vector machines, we obtained an estimated classification test accuracy of 100% for the distinction between stage I and advanced-stage disease and 76.92% for the distinction between platin-resistant versus platin-sensitive disease in FIGO stage III/IV. These results indicate that gene expression patterns could be useful in clinical management of ovarian cancer. |
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Authors:
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F De Smet; N L M M Pochet; K Engelen; T Van Gorp; P Van Hummelen; K Marchal; F Amant; D Timmerman; B L R De Moor; I B Vergote |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 16 Suppl 1 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 147-51 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering ESAT-SCD, K.U.Leuven, Leuven-Heverlee, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy,
genetics*,
pathology* Adult Aged Aged, 80 and over Antineoplastic Agents / therapeutic use Drug Resistance, Neoplasm Female Gene Expression Profiling Humans Middle Aged Neoplasm Staging Oligonucleotide Array Sequence Analysis Ovarian Neoplasms / drug therapy, genetics*, pathology* Platinum Compounds / therapeutic use Predictive Value of Tests |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Platinum Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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