Document Detail

Predicting change of hemoglobin after transfusion in hemodynamically stable anemic patients in emergency department.
MedLine Citation:
PMID:  20154545     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate factors associated with change of post-transfusion hemoglobin level, and to derive an equation that predicts post-transfusion changes in hemoglobin levels in hemodynamically stable anemic patients who visited emergency department. METHODS: A retrospective medical record review of patients who were hemodynamically stable and transfused with packed red blood cells was undertaken. Patients were randomly divided into two groups. One group (derivation group, 70% of total patients) was analyzed for factors associated with changes in post-transfusion hemoglobin levels, and linear regression analysis was performed to derive a prediction equation. The derived prediction equation was then externally validated with the other group (validation group, 30% of total patients). RESULTS: A total of 196 patients were enrolled. The 137 patients (70% of total patients) in the derivation group were analyzed for factors associated with changes in post-transfusion hemoglobin. Of those, body surface area and initial hemoglobin level were significantly correlated with changes in post-transfusion hemoglobin levels (p < 0.05). From these variables, linear regression analysis resulted in a prediction equation. The derived equation was validated externally with the 59 patients (30% of total patients) in the validation group and found to have an excellent correlation (r = 0.73, intraclass correlation = 0.84, p < 0.05). CONCLUSIONS: Post-transfusion hemoglobin level in hemodynamically stable adult patients was associated with initial hemoglobin levels and body surface area. These factors must be considered when transfusing hemodynamically stable adult patients with anemia.
Jae Hyuk Lee; Dong Hoon Kim; Kyuseok Kim; Joong Eui Rhee; Tae Youn Kim; You Hwan Jo; Jin Hee Lee; Gil Joon Suh; Seung Sik Hwang; Christopher C Lee; Adam J Singer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  68     ISSN:  1529-8809     ISO Abbreviation:  J Trauma     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  AIM; IM    
Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea.
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MeSH Terms
Anemia / physiopathology,  therapy*
Body Surface Area
Emergency Service, Hospital
Erythrocyte Transfusion*
Hemoglobins / analysis
Linear Models
Middle Aged
Retrospective Studies
Reg. No./Substance:

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