Document Detail

Predicting caffeine plasma concentrations resulting from consumption of food or beverages: a simple method and its origin.
MedLine Citation:
PMID:  3243174     Owner:  NLM     Status:  MEDLINE    
Multiple dosage regimens for therapeutic agents are commonly comprised of a constant dosing interval and a constant dose size. This is not true for the ingestion of a pharmacologically active agent that is a component in a dietary source. Caffeine is contained in foods and beverages that are regular components of the diet for many people. Because daily intake is unsystematic, a computer program was written to simulate caffeine plasma concentration-time courses following ingestion of variable amounts on irregular schedules. Literature values for caffeine pharmacokinetics, for the caffeine content in various foods and beverages, and for consumer habits were employed to simulate various caffeine plasma concentration-time courses. By searching for predictable traits in a wide variety of plasma concentration-time courses representing normal adults, a simple noncomputer method was developed to allow individuals to estimate caffeine plasma concentrations based on personal intake habits. Changes in the time courses due to smoking, oral contraceptive use, and liver disease, all of which alter caffeine pharmacokinetics, were also examined.
R W Pfeifer; R E Notari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug intelligence & clinical pharmacy     Volume:  22     ISSN:  0012-6578     ISO Abbreviation:  Drug Intell Clin Pharm     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0212457     Medline TA:  Drug Intell Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  953-9     Citation Subset:  IM    
Hospital Pharmacy, Ohio State University Hospitals, Columbus.
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MeSH Terms
Caffeine / blood*,  pharmacokinetics
Reg. No./Substance:
0/Coffee; 58-08-2/Caffeine

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