| Predicting behavioral problems in craniopharyngioma survivors after conformal radiation therapy. | |
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MedLine Citation:
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PMID: 19191345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although radiation therapy is a primary treatment for craniopharyngioma, it can exacerbate existing problems related to the tumor and pre-irradiation management. Survival is often marked by neurologic deficits, panhypopituitarism, diabetes insipidus, cognitive deficiencies, and behavioral and social problems. PROCEDURE: The Achenbach Child Behavior Checklist (CBCL) was used to evaluate behavioral and social problems during the first 5 years of follow-up in 27 patients with craniopharyngioma treated with conformal radiation therapy. RESULTS: All group averages for the CBCL scales were within the age-typical range at pre-irradiation baseline. Extent of surgical resection was implicated in baseline differences for the internalizing, externalizing, behavior problem and social scores. Significant longitudinal changes were found in internalizing, externalizing, behavior problem and school scores that correlated with tumor and treatment-related factors. CONCLUSIONS: The most common variables implicated in post-irradiation behavioral and social problems were CSF shunting, presence of an Ommaya reservoir, diabetes insipidus, and low pre-irradiation growth hormone levels. |
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Authors:
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Eugenia P Dolson; Heather M Conklin; Chenghong Li; Xiaoping Xiong; Thomas E Merchant |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 52 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-04-13 Completed Date: 2009-05-05 Revised Date: 2011-02-24 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 860-4 Citation Subset: IM |
Affiliation:
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Division of Radiation Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child Behavior Disorders / psychology* Clinical Trials, Phase II as Topic Craniopharyngioma / psychology*, radiotherapy* Female Follow-Up Studies Humans Longitudinal Studies Male Pituitary Neoplasms / psychology*, radiotherapy* Predictive Value of Tests Prospective Studies Radiotherapy, Conformal* Social Behavior Survivors / psychology |
| Grant Support | |
ID/Acronym/Agency:
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CA21765/CA/NCI NIH HHS; P30 CA021765-28/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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