| Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP. | |
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MedLine Citation:
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PMID: 21060045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To retrospectively validate the WINROP (weight, insulinlike growth factor I, neonatal, retinopathy of prematurity [ROP]) algorithm in a Brazilian population. WINROP aims to predict ROP and is based on longitudinal weight measurements from birth until postmenstrual age 36 weeks. WINROP has predicted 100% of severe ROP in 3 neonatal intensive care unit settings in the United States and Sweden. METHODS: In children admitted to the neonatal intensive care unit at Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, from April 2002 to October 2008, weight measurements had been recorded once a week for children screened for ROP, 366 of whom had a gestational age of 32 weeks or less. The participating children had a median gestational age of 30 weeks (range, 24-32 weeks) at birth and their median birth weight was 1215 g (range, 505-2000 g). RESULTS: For 192 of 366 children (53%), no alarm or low-risk alarm after postmenstrual age 32 weeks occurred. Of these, 190 of 192 did not develop proliferative disease. Two boys with severe sepsis who were treated for ROP received low-risk alarms at postmenstrual age 33 and 34 weeks, respectively. The remaining 174 children (47%) received high- or low-risk alarms before or at 32 weeks. Of these infants, 21 (12%) developed proliferative ROP. CONCLUSIONS: In this Brazilian population, WINROP, with limited information on specific gestational age and date of weight measurement, detected early 90.5% of infants who developed stage 3 ROP and correctly predicted the majority who did not. Adjustments to the algorithm for specific neonatal intensive care unit populations may improve the results for specific preterm populations. |
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Authors:
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Anna-Lena Hård; Chatarina Löfqvist; Joao Borges Fortes Filho; Renato Soibelmann Procianoy; Lois Smith; Ann Hellström |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Archives of ophthalmology Volume: 128 ISSN: 1538-3601 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 1432-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Birth Weight / physiology* Brazil Developing Countries* Diagnostic Techniques, Ophthalmological* False Positive Reactions Female Gestational Age Humans Incidence Infant Infant, Newborn Insulin-Like Growth Factor I / metabolism Intensive Care Units, Neonatal Male Neonatal Screening / methods* Predictive Value of Tests Retinopathy of Prematurity / classification, diagnosis* Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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