| Predicting progression to glaucoma in ocular hypertensive patients. | |
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MedLine Citation:
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PMID: 19730117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the ability of Heidelberg Retina Tomograph (HRT) Moorfields Regression Analysis (MRA) and Glaucoma Probability Score (GPS) classifications at baseline to predict glaucomatous progression in ocular hypertensive eyes. METHODS: One hundred ninety-eight ocular hypertensive subjects underwent regular HRT and visual field (VF) testing from 1993 to 2001. HRT progression was assessed using linear regression of rim area/time. VF progression was assessed by pointwise linear regression of sensitivity/time. Subjects were classified as progressing or stable at the end of the study period. The relationship between baseline abnormal (outside normal limits combined with borderline classification) MRA and GPS classification and progression status was assessed by odds ratios (ORs). RESULTS: An abnormal superotemporal MRA was the only classification found to be predictive of HRT progression in isolation (OR 3.05, 1.25-7.47). Abnormal global, superotemporal, superonasal, and temporal MRA classifications were all associated with significant ORs for predicting HRT or VF progression (OR range: 1.77-2.54). Abnormal GPS classifications were not predictive of disease behavior. Combined abnormal GPS and MRA classifications were associated with higher ORs than either classification in isolation. CONCLUSIONS: Patients with an abnormal MRA and GPS classification at presentation may be at increased risk of HRT or VF change. |
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Authors:
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Nicholas G Strouthidis; Stuart K Gardiner; Victoria M F Owen; Claudio Zuniga; David F Garway-Heath |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of glaucoma Volume: 19 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 304-9 Citation Subset: IM |
Affiliation:
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Glaucoma Research Unit, NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Diagnostic Techniques, Ophthalmological* Disease Progression Glaucoma / diagnosis*, physiopathology Humans Intraocular Pressure Middle Aged Ocular Hypertension / diagnosis*, physiopathology Ophthalmoscopy Optic Disk / pathology* Probability Prospective Studies Regression Analysis Sensitivity and Specificity Time Factors Tomography Vision Disorders / diagnosis Visual Fields |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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