Document Detail

Predicting the histology of small renal masses using preoperative dynamic contrast-enhanced magnetic resonance imaging.
MedLine Citation:
PMID:  22854134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study whether magnetic resonance imaging can predict the histologic type of small renal cell carcinoma.
METHODS: Dynamic contrast-enhanced magnetic resonance imaging was performed in 63 patients with computed tomography- or ultrasonography-suspected small (≤ 4 cm) renal cell carcinoma from February 2008 to February 2010. Percentage signal intensity change, tumor-to-cortex enhancement index during precontrast phase, corticomedullary phase, and nephrogenic phase were investigated.
RESULTS: Among the 60 patients, 42 were proven to have clear cell renal cell carcinoma and 18 patients were proven to have non-clear cell renal cell carcinoma (10 patients with papillary renal cell carcinoma, 8 patients with chromophobe renal cell carcinoma). The percentage signal intensity change in the clear cell type was higher only in the corticomedullary phase (P = .002). The tumor-to-cortex enhancement index in the clear cell type was higher in the corticomedullary and nephrogenic phases (P = .007 and P = .041, respectively). The most valuable marker was percentage signal intensity change in the corticomedullary phase (area under the receiver operating characteristic curve 0.85). The cut-off value of percentage signal intensity change in the corticomedullary phase was 173%, and the sensitivity and specificity were 81% and 87.5%, respectively.
CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging could be useful for discriminating the clear cell type from non-clear cell type in small renal cell carcinoma with high sensitivity and specificity.
Jae Heon Kim; Jae Hyun Bae; Kwang Woo Lee; Min Eui Kim; Seong Jin Park; Jae Young Park
Related Documents :
569184 - Effect of interferon on the cell cycle of balb/c 3t3 cells.
1277184 - Flow microfluorimetric analysis of sensitive and resistant leukemia l1210 following 1-b...
15722424 - Monitoring cell cycle distributions in mcf-7 cells using near-field photothermal micros...
1863664 - Cellular localization of dihydrofolate reductase-thymidylate synthase in carrot cells.
21920554 - Toll-like receptor 4 mediates oxidized ldl-induced macrophage differentiation to foam c...
17080014 - Expression of clusterin, xiap and survivin, and their changes by camptothecin (cpt) tre...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-31
Journal Detail:
Title:  Urology     Volume:  80     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-31     Revised Date:  2013-03-29    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  872-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Urology, Soonchunhyang University Hospital, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Area Under Curve
Carcinoma, Renal Cell / diagnosis,  pathology*
Contrast Media / diagnostic use*
Image Enhancement*
Kidney Cortex
Kidney Neoplasms / diagnosis,  pathology*
Magnetic Resonance Imaging*
Middle Aged
ROC Curve
Signal Processing, Computer-Assisted
Statistics, Nonparametric
Reg. No./Substance:
0/Contrast Media
Comment In:
Urol Oncol. 2013 Jan;31(1):133-4   [PMID:  23419730 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development and validation of novel enzyme activity methods to assess inhibition of matrix metallopr...
Next Document:  Characterization of Patients With Heterozygous Cystinuria.