| Predicted effect compartment concentration of thiopental at loss of eyelash reflex. | |
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MedLine Citation:
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PMID: 11573534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We derived the predicted effect compartment concentration of thiopental, at loss of the eyelash reflex, following three different injection regimens. Sixty patients were given thiopental for induction of anaesthesia. Twenty patients received multiple small boluses, 20 patients received a single bolus and 20 patients received an infusion. Computer simulation was then used to derive the effect compartment concentration. The median concentration was not significantly different between the three groups. EC50, derived after combining all three groups was 11.3 microg ml(-1). The EC05-EC95 range was 6.9-18.3 microg ml(-1), suggesting wide inter-individual variation. |
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Authors:
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T A Lim; K Inbasegaran |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 86 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-09-27 Completed Date: 2001-10-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 422-4 Citation Subset: IM |
Affiliation:
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Anaesthesiology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Kuala Lumpur. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Intravenous / administration & dosage*, pharmacokinetics, pharmacology Blinking / drug effects* Computer Simulation Drug Administration Schedule Female Humans Infusions, Intravenous Injections, Intravenous Male Middle Aged Models, Chemical Thiopental / administration & dosage*, pharmacokinetics, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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