Document Detail

Predicted heart rate effect of inhaled PF-00610355, a long acting β-adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  23323609     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the cardiovascular effects of a new inhaled long-acting β-adrenoceptor agonist PF-00610355 in COPD patients.
METHODS: Thirteen thousand and sixty-two heart rate measurements collected in 10 clinical studies from 579 healthy volunteers, asthma and COPD patients were analyzed. The relationship between heart rate profiles and predicted plasma concentration profiles, patient status, demographics and concomitant medication was evaluated using non-linear mixed-effects models. The median heart rate increase in COPD patients for doses of PF-00610355 up to 280 μg once daily was simulated with the final pharmacokinetic/pharmacodynamic (PKPD) model.
RESULTS: An Emax model accounting for delayed on-and off-set of the PF-00610355-induced change in heart rate was developed. The predicted potency in COPD patients was three-fold lower compared with healthy volunteers, while no difference in maximum drug effect was identified. Simulations suggested a maximum placebo-corrected increase of 2.7 (0.90-4.82) beats min(-1) in COPD patients for a PF-00610355 dose of 280 μg once daily, with 19% subjects experiencing a heart rate increase of more than 20 beats min(-1) compared with 8% in the placebo group.
CONCLUSIONS: This PKPD analysis supports the clinical observation that no relevant effects of PF-00610355 on heart rate in COPD patients should be expected for doses up to 280 μg once daily.
Paul Matthias Diderichsen; Eugène Cox; Steven W Martin; Adriaan Cleton; Jakob Ribbing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  76     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-23     Completed Date:  2014-08-04     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  752-62     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. British Journal of Clinical Pharmacology © 2013 The British Pharmacological Society.
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MeSH Terms
Administration, Inhalation
Adrenergic beta-2 Receptor Agonists / administration & dosage,  pharmacology*
Asthma / drug therapy*
Benzeneacetamides / administration & dosage,  pharmacology*
Clinical Trials as Topic
Computer Simulation
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Middle Aged
Models, Biological*
Nonlinear Dynamics
Pulmonary Disease, Chronic Obstructive / drug therapy*
Sulfonamides / administration & dosage,  pharmacology*
Young Adult
Reg. No./Substance:
0/Adrenergic beta-2 Receptor Agonists; 0/Benzeneacetamides; 0/N-((4'-hydroxybiphenyl-3-yl)methyl)-2-(3-(2-((-2-hydroxy-2-(4-hydroxy-3-((methylsulfonyl)amino)phenyl)ethyl)amino)-2-methylpropyl)phenyl)acetamide; 0/Sulfonamides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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