Document Detail


Predictability of peak serum gentamicin concentration with dosage based on body surface area.
MedLine Citation:
PMID:  758394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined gentamicin dosage based on body surface area (60 mg/m2 intravenously every eight hours) as a means of attaining therapeutic but nontoxic serum concentrations in 58 patients ranging in age from 0.7 to 73 years. All but one patient had peak serum levels between 3.4 and 8.0 microgram/ml. The mean serum gentamicin half-life was shorter in patients less than 10 years of age (76 minutes) than in patients aged 10 to 50 years (116 minutes) and in patients aged 50 to 63 years (184 minutes) (all significant at P less than 0.01). We conclude that gentamicin dosage based on body surface area produces uniform peak serum gentamicin concentrations in both children and adults, and that the safety and efficacy of a shorter dosage interval for children deserves investigation.
Authors:
G R Siber; A L Smith; M J Levin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  94     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-02-21     Completed Date:  1979-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Body Surface Area*
Cachexia / blood
Child
Child, Preschool
Extracellular Space / metabolism
Gentamicins / administration & dosage*,  blood*
Half-Life
Humans
Infant
Middle Aged
Obesity / blood
Regression Analysis
Chemical
Reg. No./Substance:
0/Gentamicins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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