Document Detail


Prediagnostic plasma vitamin B6 (pyridoxal 5'-phosphate) and survival in patients with colorectal cancer.
MedLine Citation:
PMID:  23340905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Higher plasma pyridoxal 5'-phosphate (PLP) levels are associated with a decreased incidence of colorectal cancer, but the influence of plasma PLP on survival of patients with colorectal cancer is unknown. We prospectively examined whether prediagnostic plasma PLP levels are associated with mortality among colorectal cancer patients.
METHODS: We included 472 incident cases of colorectal cancer identified in the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians' Health Study from 1984 to 2002. The patients provided blood samples two or more years before cancer diagnosis. Stratified Cox proportional hazards models were used to calculate hazard ratios (HR) with 95 % confidence intervals (CI) adjusted for other risk factors for cancer survival.
RESULTS: Higher plasma PLP levels were not associated with a significant reduction in colorectal cancer-specific (169 deaths) or overall mortality (259 deaths). Compared with patients who had less than 45 pmol/ml of plasma PLP (median: 33.6 pmol/ml), those who had 110 pmol/ml or higher levels (median: 158.8 pmol/ml) had multivariable HRs of 0.85 (95 % CI 0.50-1.45, p trend = 0.37) and 0.87 (95 % CI 0.56-1.35, p trend = 0.24) for colorectal cancer-specific and overall mortality. Higher plasma PLP levels, however, seemed to be associated with better survival among patients who had lower circulating 25-hydroxyvitamin D3 levels (<26.5 ng/ml) (p interaction ≤.005).
CONCLUSIONS: Higher prediagnostic plasma PLP levels were not associated with an improvement on colorectal cancer survival overall. Further research is needed to clarify the influence of vitamin B6 on colorectal cancer progression and survival.
Authors:
Youjin Je; Jung Eun Lee; Jing Ma; Xuehong Zhang; Eunyoung Cho; Bernard Rosner; Jacob Selhub; Charles S Fuchs; Jeffrey Meyerhardt; Edward Giovannucci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-23
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  24     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-12     Revised Date:  2014-07-15    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  719-29     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms / blood,  diagnosis,  mortality*
Female
Follow-Up Studies
Health Personnel*
Humans
Incidence
Male
Middle Aged
Neoplasm Staging
Prognosis
Prospective Studies
Survival Rate
Tumor Markers, Biological / blood*
Vitamin B 6 / blood*
Vitamin B Complex / blood*
Grant Support
ID/Acronym/Agency:
CA55075/CA/NCI NIH HHS; CA87969/CA/NCI NIH HHS; P01 CA055075/CA/NCI NIH HHS; P01 CA087969/CA/NCI NIH HHS; R01 CA149222/CA/NCI NIH HHS; R01 CA169141/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; 12001-76-2/Vitamin B Complex; 8059-24-3/Vitamin B 6
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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