Document Detail


Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: the EPIC cohort.
MedLine Citation:
PMID:  23390184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design.
METHODS: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality.
RESULTS: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the follow-up period (mean follow-up = 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p = 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio = 0.93, 95% confidence interval 0.86-0.99 per kg/m(2)); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio = 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p = 0.056).
CONCLUSION: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality.
Authors:
Valentina Gallo; Petra A Wark; Mazda Jenab; Neil Pearce; Carol Brayne; Roel Vermeulen; Peter M Andersen; Goran Hallmans; Andreas Kyrozis; Nicola Vanacore; Mariam Vahdaninia; Verena Grote; Rudolf Kaaks; Amalia Mattiello; H Bas Bueno-de-Mesquita; Petra H Peeters; Ruth C Travis; Jesper Petersson; Oskar Hansson; Larraitz Arriola; Juan-Manuel Jimenez-Martin; Anne Tjønneland; Jytte Halkjær; Claudia Agnoli; Carlotta Sacerdote; Catalina Bonet; Antonia Trichopoulou; Diana Gavrila; Kim Overvad; Elisabete Weiderpass; Domenico Palli; J Ramón Quirós; Rosario Tumino; Kay-Tee Khaw; Nicholas Wareham; Aurelio Barricante-Gurrea; Veronika Fedirko; Pietro Ferrari; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Heiner Boeing; Matthaeus Vigl; Lefkos Middleton; Elio Riboli; Paolo Vineis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-06
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-04-18     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-38     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiopathology*
Adult
Aged
Amyotrophic Lateral Sclerosis / diagnosis,  epidemiology*,  mortality
Anthropometry / methods
Body Mass Index*
Cohort Studies
Female
Health Surveys
Humans
Male
Middle Aged
Prospective Studies
Risk
Time Factors
Grant Support
ID/Acronym/Agency:
11692//Cancer Research UK; 14136//Cancer Research UK; G1000143//Medical Research Council
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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