| Prediabetes as a therapeutic target. | |
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MedLine Citation:
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PMID: 21062906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The term "prediabetes" is used to describe a condition that involves impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). IGT is defined by a 2-h oral glucose tolerance test plasma glucose concentration >140 mg/dL (7.8 mmol/L) but <200 mg/dL (11.1 mmol/L), and IFG is defined by a fasting plasma glucose concentration ≥100 mg/dL (5.6 mmol/L), but <126 mg/dL (7.0 mmol/L). Studies have shown that people with prediabetes tend to develop type 2 diabetes within 10 years and are at increased risk for cardiovascular disease and death even before the development of diabetes. CONTENT: In this minireview we discusses the epidemiology, pathophysiology, and clinical implications of prediabetes. The rationale for therapeutic intervention in people with prediabetes, the goals of intervention, and the specific tools for intervention are presented. Emphasis is placed on data from randomized controlled clinical trials, whenever such data are available. SUMMARY: Approximately 57 million Americans have prediabetes and are consequently at risk for cardiometabolic complications. Lifestyle modifications (dietary restriction and exercise) and certain medications can prevent the development of diabetes in persons with prediabetes. Lifestyle intervention also has been demonstrated to decrease cardiovascular disease risk markers, although data on clinical events are lacking. |
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Authors:
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Omid Rad Pour; Samuel Dagogo-Jack |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-11-09 |
Journal Detail:
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Title: Clinical chemistry Volume: 57 ISSN: 1530-8561 ISO Abbreviation: Clin. Chem. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-03-22 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: United States |
Other Details:
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Languages: eng Pagination: 215-20 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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prevention & control Diabetes Mellitus / prevention & control Humans Hypoglycemic Agents / therapeutic use Life Style Practice Guidelines as Topic Prediabetic State / epidemiology, physiopathology, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00211/RR/NCRR NIH HHS; R01 DK067269/DK/NIDDK NIH HHS; R01 DK067269-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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