Document Detail


Predator-induced opioid and non-opioid mediated analgesia in young meadow voles: sex differences and developmental changes.
MedLine Citation:
PMID:  8402149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined developmental changes in the nociceptive responses of male and female meadow voles, Microtus pennsylvanicus, exposed to a garter snake, a natural predator of young voles. After 15 min of exposure to the presence of a garter snake, neonatal-juvenile voles (5-20 days of age) displayed naloxone (1.0 mg/kg)-sensitive opioid mediated analgesic responses, while after a brief 30-s exposure to the snake, voles displayed a higher amplitude, non-opioid analgesia that was insensitive to naloxone and blocked by the serotonin-1A (5-HT1A) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin. The levels of opioid and non-opioid mediated analgesia declined during development as the threat presented by the snake decreased. Young female voles also displayed a significantly greater non-opioid, 5-HT1A sensitive analgesia than males, with no significant sex differences in the lower amplitude opioid analgesia. These results indicate that young (neonatal) meadow voles that are exposed to a naturally threatening stimulus display sexually dimorphic analgesic responses. These findings also illustrate the need to consider the ecological context when examining environmentally-induced analgesia.
Authors:
L M Saksida; L A Galea; M Kavaliers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  617     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-29     Completed Date:  1993-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
Analgesia
Animals
Arvicolinae / physiology,  psychology*
Avoidance Learning / physiology*
Endorphins / physiology*
Female
Male
Naloxone / pharmacology
Predatory Behavior*
Sex Characteristics*
Chemical
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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