Document Detail

Precursor role of 15alpha-hydroxyestradiol and 15alpha-hydroxyandrostenedione in the formation of estetrol.
MedLine Citation:
PMID:  630454     Owner:  NLM     Status:  MEDLINE    
Studies were designed to elucidate the origin of estetrol (15alpha-hydroxyestriol (estra-1,3,5(10)triene-3,15alpha,17beta-tetrol) or E4) during late human pregnancy. 3H-Labelled 15alpha-hydroxyestradiol (3,15alpha-dihydroxyestra-1,3,5(10)-trien-17-one or 15E2) and 14C-labelled 17beta-estradiol (estra-1,3,5(10)-triene-3,17beta-diol or E2) were infused into the fetus during transfusion in utero for erythroblastosis fetalis, and in another study the same substrates were injected intravenously into the maternal circulation. In a third study, 3H-labelled 15alpha-hydroxyandrostenedion (15alpha-hydroxyandrost-4-ene-3,17-dione or 15delta4) and 14C-labelled E2 were infused into the fetus. Maternal urine was collected for 5--6 days, and after Glusulase hydrolysis, the following metabolites were isolated: estriol (estra-1,3,5(10)-triene-3,16alpha,17beta-triol or E3) containing 14C only and 15alpha-hydroxyestrone (3,15alpha-dihydroxyestra-1,3,5(10)-trien-17-one or 15E1), 15E2, and E4, all containing both labels. From the isotope content of these metabolites, it was concluded that E4 was derived from both fetal E2 and 15delta4 and only partially via 15E2. When administered to the fetus E2 and 15delta4 contributed approximately equal amounts to urinary E4. The yield of 15alpha-hydroxylated estrogens from E2 injected into the mother was very low indicating the predominantly fetal origin of the 15alpha-hydroxylase. 15delta4 was a better precursor than E2 for urinary 15E2.
H A Schut; J M Bowman; S Solomon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of biochemistry     Volume:  56     ISSN:  0008-4018     ISO Abbreviation:  Can. J. Biochem.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421034     Medline TA:  Can J Biochem     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
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MeSH Terms
Androstenedione / analogs & derivatives*,  metabolism
Estetrol / urine*
Estradiol / analogs & derivatives*,  metabolism
Estriol / analogs & derivatives*
Maternal-Fetal Exchange
Pregnancy Trimester, Third
Reg. No./Substance:
15183-37-6/Estetrol; 50-27-1/Estriol; 50-28-2/Estradiol; 63-05-8/Androstenedione

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