Document Detail

Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate.
MedLine Citation:
PMID:  24139044     Owner:  NLM     Status:  In-Data-Review    
Long-term ex vivo live imaging combined with unbiased sampling of cycling precursors shows that macaque outer subventricular zone (OSVZ) includes four distinct basal radial glial (bRG) cell morphotypes, bearing apical and/or basal processes in addition to nonpolar intermediate progenitors (IPs). Each of the five precursor types exhibits extensive self-renewal and proliferative capacities as well as the ability to directly generate neurons, albeit with different frequencies. Cell-cycle parameters exhibited an unusual stage-specific regulation with short cell-cycle duration and increased rates of proliferative divisions during supragranular layer production at late corticogenesis. State transition analysis of an extensive clonal database reveals bidirectional transitions between OSVZ precursor types as well as stage-specific differences in their progeny and topology of the lineage relationships. These results explore rodent-primate differences and show that primate cortical neurons are generated through complex lineages by a mosaic of precursors, thereby providing an innovative framework for understanding specific features of primate corticogenesis.
Marion Betizeau; Veronique Cortay; Dorothée Patti; Sabina Pfister; Elodie Gautier; Angèle Bellemin-Ménard; Marielle Afanassieff; Cyril Huissoud; Rodney J Douglas; Henry Kennedy; Colette Dehay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron     Volume:  80     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Stem Cell and Brain Research Institute, INSERM U846, 18 Avenue Doyen Lepine, 69500 Bron, France; Université de Lyon, Université Lyon I, 69003 Lyon, France.
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