| Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis. | |
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MedLine Citation:
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PMID: 19274439 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE AND DESIGN: Reactive oxygen and nitrogen species are involved in the pathogenesis of sepsis syndrome with peritonitis and the septic shock. The aim of this study was to determine whether ozone oxidative preconditioning (OOP) may exert beneficial effects in the prevention and treatment of sepsis syndrome in rats inoculated by the intraperitoneal route (i.p.) with fecal material and also to determine if antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) may exert protective effects against this systemic inflammatory disorder. MATERIALS AND METHODS: Male Wistar rats were used. SOD and GPx activities were determined in erythrocytes. Thiobarbituric acid reactive substances (TBARS) content as biomarkers of oxidative stress, alanine amino transferase (ALT), aspartate amino transferase (AST) and creatinine (CRE) were measured in blood serum and myeloperoxidase (MPO) in lung tissue as markers of organs damage. RESULTS: In rats submitted to OOP, SOD and GPx activities were significantly increased and it was accompanied by significant decrease of TBARS content in blood serum. OOP also significantly reduced levels of ALT, AST and CRE in blood serum as well as MPO in rat lung. CONCLUSION: The results support the important role of SOD and GPx in the protective effects of OOP against organ damage induced by fecal peritonitis in rats. |
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Authors:
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Zullyt Zamora Rodríguez; Dailén Guanche; Ricardo González Alvarez; Frank Hernández Rosales; Yaima Alonso; Siegfried Schulz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-3-10 |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: - ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Biological Assays, Department of Biomedical Research, Ozone Research Center, P.O. Box 6414, Havana, Cuba, zullyt@infomed.sld.cu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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