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Preconditioning with hypercapnic acidosis: Hope for the ischemic brain.
MedLine Citation:
PMID:  22743297     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acidosis is an important stress factor triggering cell death under ischemic stress. Accordingly, short acidic pretreatment, i.e. acidic preconditioning, has been used to protect heart and liver. Now the beneficial effect of pretreatment with hypercapnic acidosis against ischemia/reperfusion-induced cell death has also been shown for the brain. The possible underlying cellular mechanisms of the protection as well as role of acidic and hypercapnic sensing are briefly discussed.
Authors:
Yury Ladilov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Clinical Pharmacology, Ruhr-University Bochum, Germany.
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