Document Detail

Preconditioning reduces infarct size but accelerates time to ventricular fibrillation in ischemic pig heart.
MedLine Citation:
PMID:  7631877     Owner:  NLM     Status:  MEDLINE    
Preconditioning protects the rat heart from ventricular arrhythmias. However, the mechanism of this beneficial effect and its existence in large animal models remain unknown. We submitted 49 pigs to 40 min of left anterior descending coronary occlusion and 2 h of reperfusion and assessed the incidence of ventricular fibrillation (VF) and time to VF. Monophasic action potential duration (MAPD) and ventricular fibrillation threshold (VFT) were measured throughout the experiment. Preconditioning significantly reduced infarct size but failed to reduce the incidence of VF either during the 40-min ischemic insult or the following reperfusion. Moreover, preconditioning accelerated the onset of VF during the prolonged ischemia; time to VF averaged 8 +/- 2 min in the preconditioned group vs. 18 +/- 2 min in the control group (P < 0.05). This premature peak of VF in preconditioned hearts was associated with a significant decrease of VFT and shortening of MAPD. This suggests that preconditioning does not limit the incidence of VF in the pig model. Rather, preconditioning decreases the time to VF in this species, likely through lowering of the VFT and shortening of the action potential duration.
M Ovize; J F Aupetit; G Rioufol; J Loufoua; X André-Fouët; Y Minaire; G Faucon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  269     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-09-01     Completed Date:  1995-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H72-9     Citation Subset:  IM    
Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Hôpital Saint Joseph et Saint Luc, France.
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MeSH Terms
Action Potentials
Coronary Disease / complications
Differential Threshold
Heart Conduction System / physiopathology
Myocardial Infarction / pathology*
Myocardial Ischemia / complications*,  physiopathology*
Reaction Time
Time Factors
Ventricular Fibrillation / etiology*
Ventricular Function

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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