| Preconditioning reduces infarct size but accelerates time to ventricular fibrillation in ischemic pig heart. | |
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MedLine Citation:
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PMID: 7631877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preconditioning protects the rat heart from ventricular arrhythmias. However, the mechanism of this beneficial effect and its existence in large animal models remain unknown. We submitted 49 pigs to 40 min of left anterior descending coronary occlusion and 2 h of reperfusion and assessed the incidence of ventricular fibrillation (VF) and time to VF. Monophasic action potential duration (MAPD) and ventricular fibrillation threshold (VFT) were measured throughout the experiment. Preconditioning significantly reduced infarct size but failed to reduce the incidence of VF either during the 40-min ischemic insult or the following reperfusion. Moreover, preconditioning accelerated the onset of VF during the prolonged ischemia; time to VF averaged 8 +/- 2 min in the preconditioned group vs. 18 +/- 2 min in the control group (P < 0.05). This premature peak of VF in preconditioned hearts was associated with a significant decrease of VFT and shortening of MAPD. This suggests that preconditioning does not limit the incidence of VF in the pig model. Rather, preconditioning decreases the time to VF in this species, likely through lowering of the VFT and shortening of the action potential duration. |
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Authors:
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M Ovize; J F Aupetit; G Rioufol; J Loufoua; X André-Fouët; Y Minaire; G Faucon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-09-01 Completed Date: 1995-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H72-9 Citation Subset: IM |
Affiliation:
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Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Hôpital Saint Joseph et Saint Luc, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Coronary Disease / complications Differential Threshold Female Heart Conduction System / physiopathology Hemodynamics Male Myocardial Infarction / pathology* Myocardial Ischemia / complications*, physiopathology* Reaction Time Swine Time Factors Ventricular Fibrillation / etiology* Ventricular Function |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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