Document Detail

Preconditioning and protection against ischaemia-reperfusion in non-cardiac organs: a place for volatile anaesthetics?
MedLine Citation:
PMID:  17555610     Owner:  NLM     Status:  MEDLINE    
There is an increasing body of evidence that volatile anaesthetics protect myocardium against ischaemic insult by a mechanism termed 'anaesthetic preconditioning'. Anaesthetic preconditioning and ischaemic preconditioning share several common mechanisms of action. Since ischaemic preconditioning has been demonstrated in organs other than the heart, anaesthetic preconditioning might also apply in these organs and have significant clinical applications in surgical procedures carrying a high risk of ischaemia-reperfusion injury. After a brief review on myocardial preconditioning, experimental and clinical data on preconditioning in non-cardiac tissues will be presented. Potential benefits of anaesthetic preconditioning during non-cardiac surgery will be addressed.
G Minguet; J Joris; M Lamy
Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-07
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  24     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  733-45     Citation Subset:  IM    
University of Liège, Department of Anaesthesia and Intensive Care Medicine, Belgium.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Ischemic Preconditioning / methods*
Ischemic Preconditioning, Myocardial / methods
Reperfusion Injury / prevention & control*
Reg. No./Substance:
0/Anesthetics, Inhalation

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