| Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats. | |
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MedLine Citation:
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PMID: 8853316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were designed to test whether preconditioning protects against chronic endothelial injury after ischemia and reperfusion. Coronary arteries were isolated from rats subjected to sham surgery or 20 min of ischemia followed by 1 h, 1 day, 1 wk, or 1 mo of reperfusion without or with preconditioning. The endothelium-dependent relaxations to acetylcholine (ACh; assessed in vitro) were markedly reduced after ischemia and 1 h of reperfusion (31 +/- 6 vs. 57 +/- 6% in sham; P < 0.01) and did not recover after longer durations of reperfusion (1 mo: 32 +/- 5 vs. 56 +/- 2%; P < 0.01). The impaired response to ACh was restored by preconditioning at all time points (1 h: 53 +/- 6; 1 mo: 65 +/- 4%). After 1 mo, the potency of ACh in preconditioned arteries was also increased compared with that in sham animals. Electron microscopy showed marked endothelial damage after 1 h of reperfusion and signs of regenerated endothelium after 1 mo of reperfusion. Both acute and chronic ultrastructural changes were prevented by preconditioning. Thus preconditioning, in addition to protecting myocardial cells, also protects against chronic reperfusion-induced endothelial injury, both in terms of functional and structural changes. |
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Authors:
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N Kaeffer; V Richard; A François; F Lallemand; J P Henry; C Thuillez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H842-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology (Groupe Vaisseaux-Coeur-Médicaments, Institut Fédératif de Recherches 23-Peptides, Rouen University Medical School, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Chronic Disease Coronary Circulation* / drug effects Coronary Vessels / ultrastructure Endothelium, Vascular / physiopathology* Ischemic Preconditioning, Myocardial* Male Microscopy, Electron Molsidomine / analogs & derivatives, pharmacology Myocardial Ischemia* Myocardial Reperfusion Injury / pathology, physiopathology*, prevention & control* Rats Rats, Wistar Serotonin / pharmacology Vasoconstriction Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 50-67-9/Serotonin; 51-84-3/Acetylcholine |
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