Document Detail

Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats.
MedLine Citation:
PMID:  8853316     Owner:  NLM     Status:  MEDLINE    
Experiments were designed to test whether preconditioning protects against chronic endothelial injury after ischemia and reperfusion. Coronary arteries were isolated from rats subjected to sham surgery or 20 min of ischemia followed by 1 h, 1 day, 1 wk, or 1 mo of reperfusion without or with preconditioning. The endothelium-dependent relaxations to acetylcholine (ACh; assessed in vitro) were markedly reduced after ischemia and 1 h of reperfusion (31 +/- 6 vs. 57 +/- 6% in sham; P < 0.01) and did not recover after longer durations of reperfusion (1 mo: 32 +/- 5 vs. 56 +/- 2%; P < 0.01). The impaired response to ACh was restored by preconditioning at all time points (1 h: 53 +/- 6; 1 mo: 65 +/- 4%). After 1 mo, the potency of ACh in preconditioned arteries was also increased compared with that in sham animals. Electron microscopy showed marked endothelial damage after 1 h of reperfusion and signs of regenerated endothelium after 1 mo of reperfusion. Both acute and chronic ultrastructural changes were prevented by preconditioning. Thus preconditioning, in addition to protecting myocardial cells, also protects against chronic reperfusion-induced endothelial injury, both in terms of functional and structural changes.
N Kaeffer; V Richard; A François; F Lallemand; J P Henry; C Thuillez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H842-9     Citation Subset:  IM    
Department of Pharmacology (Groupe Vaisseaux-Coeur-Médicaments, Institut Fédératif de Recherches 23-Peptides, Rouen University Medical School, France.
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MeSH Terms
Acetylcholine / pharmacology
Chronic Disease
Coronary Circulation* / drug effects
Coronary Vessels / ultrastructure
Endothelium, Vascular / physiopathology*
Ischemic Preconditioning, Myocardial*
Microscopy, Electron
Molsidomine / analogs & derivatives,  pharmacology
Myocardial Ischemia*
Myocardial Reperfusion Injury / pathology,  physiopathology*,  prevention & control*
Rats, Wistar
Serotonin / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 50-67-9/Serotonin; 51-84-3/Acetylcholine

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