Document Detail

Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias.
MedLine Citation:
PMID:  3425747     Owner:  NLM     Status:  MEDLINE    
Hearts of anesthetized rats (n = 12 in each of 7 groups) were subjected to 5 min of regional ischemia; on reperfusion, 100% exhibited ventricular tachycardia (VT), 83% ventricular fibrillation (VF), and the mean total number of premature ventricular complexes (PVC) was 681 +/- 220. Hearts were then reverted to sinus rhythm and allowed to "recover" for 10, 20, 30, 60, 120 min, 1 or 3 days; they were again subjected to 5 min of ischemia and reperfusion. With recovery periods of 10 and 20 min a second episode of ischemia and reperfusion resulted in very few arrhythmias: 0% VF in both instances, 17 and 8% VT, and only 4 +/- 3 and 9 +/- 5 PVC, respectively. As the recovery period increased to 3 days there was a progressive return of vulnerability to reperfusion-induced arrhythmias. However, this return was slow, such that with a recovery time of 60 min, only 33% of hearts fibrillated. In additional studies, hearts were subjected to 0.5, 1.0, 3.0, or 5 min of regional ischemia, 10 min of reperfusion, 5 min of ischemia, and a second period of reperfusion. The vulnerability to arrhythmias during the second period of reperfusion was found to correlate inversely with the incidence of arrhythmias elicited by the first episode of reperfusion. We propose that a very short period of ischemia and reperfusion "preconditions" the myocardium so as to influence the vulnerability of the heart to subsequent reperfusion-induced arrhythmias, and that "recovery" from this effect can take a substantial period of time.
K Shiki; D J Hearse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  253     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1470-6     Citation Subset:  IM    
Cardiovascular Research, Rayne Institute, St. Thomas' Hospital, London, United Kingdom.
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MeSH Terms
Arrhythmias, Cardiac / etiology*
Coronary Circulation
Coronary Disease / complications*,  physiopathology
Heart / physiopathology
Rats, Inbred Strains
Time Factors
Ventricular Fibrillation / etiology

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