Document Detail

Preconditioning by brief ischaemic episodes in the isolated rat heart assessed by 31P NMR spectroscopy: dissociation between metabolic and functional recovery?
MedLine Citation:
PMID:  7624739     Owner:  NLM     Status:  MEDLINE    
31P NMR spectroscopy was used to investigate whether improved functional recovery in ischaemic preconditioning was due to improved metabolic recovery in isolated rat hearts. The preconditioning stimulus was global ischaemia of 1 or 4 min followed by 12 min of reperfusion (Langendorff mode). The hearts were then subjected to a main ischaemic period of 16 min and 40 min of reperfusion. Functional and metabolic recoveries of hearts were compared to a control group subjected only to the main ischaemia. Preconditioning improved recovery of contractile function during the final reperfusion. Thus left ventricular developed pressure (LVDP) and heart rate (HR) product after 40 min of reperfusion recovered to 56, 67 and 68% in the control group, 1 min group and 4 min group, respectively. However, the metabolic recovery was comparable in all groups. CrP and ATP recovered to levels of 67-78% (CrP) and 35-41% (ATP), and pH to a level of 7.13-7.15 (not different from baseline values) at the end of the final reperfusion. We conclude that the improved functional recovery in preconditioning is not due to a higher level of high energy phosphates or less acidosis during the final reperfusion.
J Schjøtt; O E Bakøy; R A Jones; T Southon; P Jynge
Related Documents :
7596119 - Glibenclamide, a blocker of atp-sensitive potassium channels, abolishes infarct size li...
8602749 - The role of spreading depression in focal ischemia evaluated by diffusion mapping.
12617989 - Influence of antithrombin on ischemia/reperfusion injury in the isolated blood-free per...
15528229 - Calpain inhibitor-1 protects the rat heart from ischemia-reperfusion injury: analysis b...
1742769 - Failure of cyclo-oxygenase inhibition to protect against arrhythmias induced by ischaem...
11068179 - Glycogen turnover and anaplerosis in preconditioned rat hearts.
11547129 - Effects of selective autonomic and pudendal denervation on the urethral function and de...
9568349 - Arterial and venous plasma catecholamines during submaximal steady-state exercise.
821329 - Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  55     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  67-78     Citation Subset:  IM    
Department of Pharmacology and Toxicology, University Medical Centre, University of Trondheim, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Blood Pressure
Heart / physiopathology*
Heart Rate
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Myocardial Contraction
Myocardial Ischemia / metabolism,  physiopathology*
Myocardial Reperfusion*
Myocardium / metabolism
Phosphates / metabolism
Phosphocreatine / metabolism
Rats, Wistar
Ventricular Function, Left
Reg. No./Substance:
0/Phosphates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Zinc heparin introduces a preanalytical error in the measurement of ionized calcium concentration.
Next Document:  Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and ...