Document Detail


Preconceptional folate intake and malformations of the cardiac outflow tract. Baltimore-Washington Infant Study Group.
MedLine Citation:
PMID:  9430276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared cases with outflow tract defects (N = 126) with controls representative of the same birth cohort (N = 679). Infants with clinically recognized syndromes were excluded. Daily total maternal folate intake of > or =245 microg was inversely related to risk of cardiac outflow tract defects among those with transposition (odds ratio estimates: 0.65, 0.78, and 0.76 with increasing quartile of daily folate intake), but positively related among those with normally related vessels (corresponding odds ratio estimates: 1.18, 1.59, and 1.68). This difference disappeared when maternal intake of supplemental folic acid of > or =400 microg compared with <400 microg was considered, excluding dietary intake [odds ratio (OR) = 1.04; 95% confidence interval (CI) = 0.5-2.2 for infants with transposition, and OR = 0.91; 95% CI = 0.5-1.8 for those without transposition of the great arteries].
Authors:
K S Scanlon; C Ferencz; C A Loffredo; P D Wilson; A Correa-Villaseñor; M J Khoury; W C Willett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  9     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Affiliation:
Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
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MeSH Terms
Descriptor/Qualifier:
Dietary Supplements*
Female
Folic Acid / administration & dosage*,  therapeutic use
Heart Defects, Congenital / epidemiology*,  prevention & control
Humans
Infant, Newborn
Logistic Models
Odds Ratio
Preconception Care*
Pregnancy
Transposition of Great Vessels / epidemiology,  prevention & control
Grant Support
ID/Acronym/Agency:
R-37 HL25629/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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