Document Detail


Preconception serum DDT and pregnancy loss: a prospective study using a biomarker of pregnancy.
MedLine Citation:
PMID:  16120699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies of pregnancy losses and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) were limited because they did not include losses prior to clinical detection of pregnancy and because exposures were measured after the pregnancies of interest. The authors examined the association of preconception serum total DDT (sum of DDT isomers and metabolites) concentration and subsequent pregnancy losses in 388 newly married, nonsmoking, female textile workers in China between 1996 and 1998. Upon stopping contraception, subjects provided daily urine specimens and records of vaginal bleeding for up to 1 year or until clinical pregnancy. Daily urinary human chorionic gonadotropin was assayed to detect conception and early pregnancy losses, and pregnancies were followed to detect clinical spontaneous abortions. There were 128 (26%) early pregnancy losses in 500 conceptions and 36 (10%) spontaneous abortions in 372 clinical pregnancies. Subjects were grouped in tertiles by preconception serum total DDT concentration (group 1: 5.5-22.9 ng/g; group 2: 23.0-36.5 ng/g; group 3: 36.6-113.3 ng/g). Compared with group 1, group 2 had adjusted relative odds of early pregnancy losses of 1.23 (95% confidence interval (CI): 0.72, 2.10), and group 3 had adjusted odds of 2.12 (95% CI: 1.26, 3.57). The relative odds of early pregnancy losses associated with a 10-ng/g increase in serum total DDT were 1.17 (95% CI: 1.05, 1.29). The small number of spontaneous abortions following clinical detection of pregnancy were not associated with serum total DDT. In this population, there was a positive, monotonic, exposure-response association between preconception serum total DDT and the risk of subsequent early pregnancy losses.
Authors:
Scott A Venners; Susan Korrick; Xiping Xu; Changzhong Chen; Wenwei Guang; Aiqun Huang; Larisa Altshul; Melissa Perry; Lingling Fu; Xiaobin Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2005-08-24
Journal Detail:
Title:  American journal of epidemiology     Volume:  162     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-12-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  709-16     Citation Subset:  IM    
Affiliation:
Department of Environmental Health, Harvard School of Public Health, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / blood*,  chemically induced,  epidemiology
Adult
Biological Markers / blood*,  urine
China / epidemiology
Chorionic Gonadotropin / urine
DDT / adverse effects,  blood*
Environmental Exposure / analysis*
Female
Follow-Up Studies
Humans
Incidence
Preconception Care
Pregnancy
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
1R01 ES008957/ES/NIEHS NIH HHS; 1R01 ES08337/ES/NIEHS NIH HHS; 1R01 ES11682/ES/NIEHS NIH HHS; 1R01 HD32505/HD/NICHD NIH HHS; ES-00002/ES/NIEHS NIH HHS; K01 ES12052/ES/NIEHS NIH HHS; P01 ES06198/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 50-29-3/DDT
Comments/Corrections
Comment In:
Am J Epidemiol. 2005 Oct 15;162(8):726-8   [PMID:  16120697 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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