Document Detail


Preconception counseling for women with thrombophilia.
MedLine Citation:
PMID:  17082685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inherited thrombophilias are a heterogeneous group of coagulation disorders that predispose individuals to thromboembolic events. This group of conditions is the major risk factor for thromboembolism during pregnancy and the puerperium. In addition, thrombophilias have been associated with several adverse obstetric events, including pregnancy loss, preeclampsia, placental abruption, and intrauterine growth restriction. An increased risk for these obstetric complications has prompted many authorities to recommend screening and treating pregnant women for thrombophilias. Optimal obstetric management, however, is controversial as thrombophilias are common and many affected individuals are asymptomatic. Indeed, pregnancy outcome in most women with thrombophilias is normal. The most commonly identified inherited thrombophilias are the factor V Leiden and prothrombin G20210A gene mutations. More rare thrombophilias include protein C and S deficiencies, antithrombin III deficiency. Although relatively common, the association between hyperhomocysteinemia and associated mutations (such as the C677 T methylenetetrahydro-folate reductase) and obstetric complications is controversial.
Authors:
Robert M Silver; Jennifer E Warren
Related Documents :
25356075 - The pregnancy outcome in patients with minor β-thalassemia.
9062725 - Recurrent miscarriages as an indication for percutaneous tricuspid valvuloplasty during...
22439605 - Increased composite maternal and neonatal morbidity associated with ultrasonographicall...
1579895 - The pregnant antithrombin iii deficient patient: management without antithrombin iii co...
23262935 - Independent relation of maternal prenatal factors to early childhood obesity in the off...
7794845 - The influence of maternal haemoglobin and ferritin on mid-pregnancy placental volume.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  49     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-07-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  906-19     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA. Bob.Silver@hsc.utah.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Factor V
Female
Genetic Counseling
Genetic Testing*
Humans
Mutation
Pregnancy
Pregnancy Complications, Hematologic / prevention & control*
Pregnancy Outcome*
Prenatal Care*
Prothrombin / genetics
Thrombophilia / complications*,  genetics
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of unfractionated heparin and low molecular weight heparins in pregnancy.
Next Document:  Multislice computed tomography in planning nephron-sparing surgery in a prospective study with 76 pa...