Document Detail

Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis.
MedLine Citation:
PMID:  11493721     Owner:  NLM     Status:  MEDLINE    
Offspring of women with pregestational diabetes mellitus are at increased risk for congenital malformations, largely attributable to poor periconceptional glycaemic control. We assessed the effect of preconception care in reducing congenital malformations, in a meta-analysis of published studies of preconception care in women with diabetes mellitus. Articles were retrieved from Medline (1970 to June 2000) and Embase (1980 to June 2000), and data abstracted by two independent reviewers. The rates and relative risks (RR) for major and minor congenital malformations were pooled from all eligible studies using a random effects model, as were early first-trimester glycosylated haemoglobin values. In 14 cohort studies, major congenital malformations were assessed among 1192 offspring of mothers who had received preconception care, and 1459 offspring of women who had not. The pooled rate of major anomalies was lower among preconception care recipients (2.1%) than non-recipients (6.5%) (RR 0.36, 95%CI 0.22-0.59). In nine studies, the risk for major and minor anomalies was also lower among women who received preconception care (RR 0.32, 95%CI 0.17-0.59), as were the early first-trimester mean glycosylated haemoglobin values (pooled mean difference: 2.3%, 95%CI 2.1-2.4). Women who received preconception care were, on average, 1.8 years older than non-recipients, and fewer smoked (19.6% vs. 30.2%). Only one study described the routine use of periconception folic acid. Out-patient preconception care probably reduces the risk of major congenital anomalies among the offspring of women with pregestational diabetes mellitus. Because many women with diabetes neither plan their pregnancy nor achieve adequate glycaemic control before conception, strategies are needed to improve access to these programs, and to maximize those interventions associated with improved pregnancy outcome, such as smoking cessation and folic acid use.
J G Ray; T E O'Brien; W S Chan
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  94     ISSN:  1460-2725     ISO Abbreviation:  QJM     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-08     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  435-44     Citation Subset:  IM    
Division of Obstetrical Medicine, Department of Medicine, Women's College Campus, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.
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MeSH Terms
Confidence Intervals
Diabetes Mellitus, Type 1 / blood,  therapy*
Diabetes Mellitus, Type 2 / blood,  therapy*
Folic Acid / therapeutic use
Hemoglobin A, Glycosylated / analysis
Preconception Care*
Pregnancy Trimester, First
Pregnancy in Diabetics / blood,  therapy*
Publication Bias
Risk Factors
Smoking Cessation
Treatment Outcome
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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