Document Detail


Preconception biomarkers of allostatic load and racial disparities in adverse birth outcomes: the Bogalusa Heart Study.
MedLine Citation:
PMID:  24117472     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Large disparities in adverse birth outcomes persist between African American and white women in the US despite decades of research, policy, and public health intervention. Allostatic load is an index of dysregulation across multiple physiologic systems that results from chronic exposure to stress in the physical and socio-cultural environment which may lead to earlier health deterioration among racially or socio-economically disadvantaged groups. The purpose of this investigation was to examine relationships between maternal biomarkers of allostatic load prior to conception and the occurrence of preterm birth and small for gestational age infants among a cohort of white and African American women participants in the Bogalusa Heart Study.
METHODS: Data from women participants were linked to the birth record of their first-born infant. Principal components analysis was used to construct an index of allostatic load as a summary of the weighted contribution of nine biomarkers representing three physiologic domains: cardiovascular, metabolic, and immune systems. A series of Poisson regression models based on samples ranging from 1467 to 375 women were used to examine race, individual biomarkers of allostatic load, and quartiles of the allostatic load index as predictors of preterm birth (n = 150, 10.2%) and small for gestational age (n = 135, 9.2%).
RESULTS: There was no evidence of a relationship between maternal preconception allostatic load and either adverse birth outcome in this sample. Further, there was no evidence of effect modification of by race or education.
CONCLUSIONS: More work is needed in understanding the biological mechanisms linking social inequities to racial disparities in adverse birth outcomes.
Authors:
Maeve Wallace; Emily Harville; Katherine Theall; Larry Webber; Wei Chen; Gerald Berenson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-10-10
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  27     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-18     Completed Date:  2014-07-17     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-97     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans
Allostasis*
Biological Markers / analysis*
European Continental Ancestry Group
Female
Health Status Disparities*
Humans
Infant, Newborn
Louisiana
Middle Aged
Pregnancy
Pregnancy Outcome / ethnology*
Premature Birth / ethnology*
Young Adult
Grant Support
ID/Acronym/Agency:
AG-16592/AG/NIA NIH HHS; ES-021724/ES/NIEHS NIH HHS; T32 HD057780/HD/NICHD NIH HHS; T32HD057780/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
Paediatr Perinat Epidemiol. 2013 Nov;27(6):507-8   [PMID:  24117491 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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