Document Detail

Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin.
MedLine Citation:
PMID:  18249202     Owner:  NLM     Status:  MEDLINE    
Osteoprotegerin (OPG) has recently been implicated in human atherogenesis. Abdominal obesity represents an established risk factor for the onset and development of atherosclerotic damage. The aim of the present study was to investigate the link between OPG and abdominal fat and the relationship to precocious features of atherosclerotic disease such as brachial flow-mediated vasodilation (FMV) and the intima-media thickening (IMT) in 195 white postmenopausal women (age range, 43-75 years). The study population was divided into 2 groups: group 1-waist circumference <80 cm and group 2-waist circumference > or = 80 cm. Group 2 had higher menopausal years, body mass index, low-density lipoprotein cholesterol, triglycerides, C-reactive protein, and carotid IMT. High-density lipoprotein cholesterol was higher in group 1. Afterward, these groups were divided on the basis of a cutoff value of OPG (6.85 pmol/L) that was the median of its distribution: patients with OPG < or = 6.85 pmol/L were OPG(-), and those with OPG >6.85 pmol/L were OPG(+). The OPG(+) subjects in both had lower brachial FMV and higher carotid IMT in comparison with OPG(-) subjects. At the multivariate regression analysis, waist circumference, high-density lipoprotein cholesterol, C-reactive protein, and OPG were predictors of carotid mean IMT (beta = 0.55, P = .001; beta = -0.14, P = .001; beta = 0.16, P = .001; and beta = 0.14, P = .05, respectively) and age, OPG, low-density lipoprotein cholesterol, and brachial diameter of brachial FMV (beta = -0.13, P = .05; beta = -0.25, P = .001; beta = -0.14, P = .024; and beta = 0.48, P = .001, respectively). The conclusions are as follows: first, OPG levels did not appear to be conditioned by a risk factor such as abdominal obesity; and second, OPG levels are mainly linked to the evidence of vascular damage. On this basis, we could speculate that OPG levels may be considered not a cardiovascular risk condition but a defense against atherosclerotic progression.
Donatella Siepi; Simona Marchesi; Gaetano Vaudo; Graziana Lupattelli; Francesco Bagaglia; Matteo Pirro; Matteo Brozzetti; Anna Rita Roscini; Elmo Mannarino
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  57     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-5     Citation Subset:  IM    
Unit of Internal Medicine, Angiology and Atherosclerosis, Ospedale S. Maria della Misericordia-University of Perugia, Piazzale Menghini, 1-06129 Perugia, Italy.
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MeSH Terms
Abdominal Fat / physiology
Aging / physiology
Arteries / pathology
Atherosclerosis / pathology,  ultrasonography
Bone Remodeling / physiology
Brachial Artery / pathology,  physiopathology
C-Reactive Protein / metabolism
Carotid Arteries / ultrasonography
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Endothelium, Vascular / pathology,  physiopathology
Middle Aged
Osteoprotegerin / physiology*
Postmenopause / physiology*
Vascular Diseases / pathology*,  ultrasonography
Vasodilation / physiology
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Osteoprotegerin; 9007-41-4/C-Reactive Protein

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