Document Detail


Preclinical models of multiple sclerosis in nonhuman primates.
MedLine Citation:
PMID:  20477025     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Biotechnology has enabled the development of specifically acting therapies for immune-mediated inflammatory disorders (IMIDs) based on biological molecules. The high species specificity precludes safety and effectivity testing in lower species (mice and rats), thus creating a need for valid experimental models in nonhuman primates (NHPs). Here, we review the creation of relevant NHP model(s) for multiple sclerosis (MS), an IMID of the human CNS. We will also discuss how the model(s) can help in the translation of a scientific principle developed in lower species into a therapy for MS.
Authors:
Bert A 't Hart; S Anwar Jagessar; Yolanda S Kap; Herbert Pm Brok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  3     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  749-61     Citation Subset:  -    
Affiliation:
Biomedical Primate Research Centre and Erasmus Medical Centre Rotterdam, Rijswijk, The Netherlands. hart@bprc.nl
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