| Preclinical investigations of a medium-chain triglyceride:fish oil emulsion III. Experiments in cultured endothelial cells. | |
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MedLine Citation:
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PMID: 17089024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion was recently reported to provoke a rapid and sustained increase in the cell phospholipid content of long-chain polyunsaturated omega3 fatty acids in both rats and human subjects. This report deals mainly with a comparison between this and other emulsions, as well as albumin-bound omega3 fatty acids, in terms of the time course, reversibility and concentration dependency for the incorporation of the omega3 fatty acids in the phospholipids of cultured endothelial cells. The results document that the new emulsion is quite efficient for a rapid and sustained enrichment of phospholipids in long-chain polyunsaturated omega3 fatty acids. The potential beneficial effects of such an enrichment in terms of aortic endothelial and cardiac function are emphasized. |
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Authors:
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Yvon A Carpentier; Isabelle Dupont; Laurence Portois; Willy J Malaisse |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 18 ISSN: 1107-3756 ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-07 Completed Date: 2007-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 1177-85 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Surgery, Brussels Free University, B-1070 Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / cytology Cattle Cell Culture Techniques Cells, Cultured Drug Evaluation, Preclinical Emulsions / chemistry, metabolism, pharmacology* Endothelium, Vascular / cytology, drug effects*, metabolism Fatty Acids, Omega-3 / analysis Fish Oils / chemistry*, pharmacology* Humans Kinetics Milk / enzymology Phospholipids / chemistry, metabolism Serum Albumin, Bovine / metabolism Triglycerides / chemistry, pharmacology* Umbilical Veins / cytology |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 0/Serum Albumin, Bovine; 0/Triglycerides |
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