Document Detail

Preclinical evaluation of new indomethacin-eluting biodegradable urethral stent.
MedLine Citation:
PMID:  22050507     Owner:  NLM     Status:  Publisher    
Purpose: To evaluate the effect of indomethacin-eluting biodegradable urethral stent on the production of inflammatory cytokines in vitro and the degradation and biocompatibility of the new stent in vivo. Materials and Methods: The effects of indomethacin and indomethacin-eluting biodegradable stent on monocyte chemoattractant protein (MCP)-1, RANTES (regulated on activation, normal T-cell expressed and secreted) and transforming growth factor (TGF)-β were measured in THP-1 cells by enzyme-linked immunosorbent assay. PLGA (copolymer of L-lactide and glycolide acid) stents coated with 50L/50D PLA (poly-lactic acid) and 2 different concentrations of indomethacin were inserted into the rabbit urethra. Stents without the drug were used as controls. Scanning electron microscopy (SEM) was used to assess the degradation of the stents. Biocompatibility was evaluated using histological analyses of the urethral specimen. The measurements were done at 3 weeks and 3 months. Results: Indomethacin and indomethacin-releasing stent material inhibited MCP-1 and RANTES production in activated THP-1 macrophages, SEM analysis revealed that indomethacin coating had no effect on the degradation process of the stents and less epithelial polyposis had developed in the indomethacin stent group. In histological analyses at 3 weeks indomethacin-eluting stents caused more calcification but no significant differences in other tissue reactions. At 3 months the indomethacin-eluting stents caused less inflammatory reaction and calcification compared to the control stents. Conclusion: Indomethacin-eluting property can be safely added to biodegradable stents without major influence on the degradation time. The development of epithelial polyposis in the urethra can be potentially reduced by the new indomethacin-eluting urethral stents.
Andres Kotsar; Riina Nieminen; Taina Isotalo; Joonas Mikkonen; Ilkka Uurto; Minna Kellomäki; Martti Talja; Eeva Moilanen; Teuvo L J Tammela
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-3
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  -     ISSN:  1557-900X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Tampere University Hospital, Department of Urology, Teiskontie 35, P.O. Box 2000, Tampere, Finland, 33521, +358503552053, +358331164358;
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