| Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models. | |
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MedLine Citation:
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PMID: 23004929 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Thiarabine was evaluated for antitumor activity in seven human leukemia, lymphoma, and myeloma xenograft models to explore the activity in hematological malignancies. Thiarabine was active against all of the human leukemia and lymphoma lines tested, being curative against HL-60 leukemia and AS283 lymphoma and effecting tumor regressions in CCRF-CEM, MOLT-4, and K-562 leukemia and RL lymphoma models, but did not exhibit any appreciable activity against RPMI-8226 myeloma. For the leukemia/lymphoma models, thiarabine was more efficacious than ara-C/palmO-ara-C (four models), clofarabine (three models), fludarabine monophosphate (five models), cladribine (four models), and gemcitabine (six models). Thiarabine warrants future clinical trials with leukemias/lymphomas. |
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Authors:
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William R Waud; Karen S Gilbert; John A Secrist |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 31 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 647-60 Citation Subset: IM |
Affiliation:
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a Southern Research Institute , Birmingham , Alabama , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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