Document Detail

Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.
MedLine Citation:
PMID:  2318326     Owner:  NLM     Status:  MEDLINE    
Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
A A Acosta; S Oehninger; J Hammer; S J Muasher; H M Liang; D L Jones
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  53     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-01     Completed Date:  1990-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-6     Citation Subset:  IM    
Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
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MeSH Terms
Abortion, Spontaneous*
Chorionic Gonadotropin / blood
Embryo Transfer
Estradiol / blood
Fertilization in Vitro*
Menstrual Cycle
Progesterone / blood
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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