Document Detail

Precision of ultrasound diagnosis of pathologically verified lesions in the brains of very preterm infants.
MedLine Citation:
PMID:  3169387     Owner:  NLM     Status:  MEDLINE    
Abnormalities detected by a mechanical sector scanner were compared 'blind' with autopsy findings in the brains of 56 infants born at less than 33 weeks gestation. Intraventricular haemorrhage was found in 53 of 112 hemispheres and had been accurately diagnosed by ultrasound (sensitivity 91 per cent; specificity 81 per cent). Isolated germinal layer haemorrhage was less successfully identified (sensitivity 61 per cent; specificity 78 per cent); false-positive diagnoses were partly due to difficulty in distinguishing haemorrhage from the normal choroid plexus in extremely preterm infants. Haemorrhagic parenchymal lesions were correctly identified in nine infants (sensitivity 82 per cent; specificity 97 per cent). Only 11 of 39 hemispheres with histological evidence of hypoxic-ischaemic injury, without marked bleeding, were correctly identified by ultrasound (sensitivity 28 per cent), mainly because of failure to detect small areas of periventricular leucomalacia and diffuse gliosis. 10 hemispheres with periventricular echodensities thought to represent leucomalacia showed no histological evidence of hypoxic-ischaemic injury (specificity 86 per cent). Ventricular dilatation in seven infants was always associated with evidence of hypoxic-ischaemic injury at autopsy.
P L Hope; S J Gould; S Howard; P A Hamilton; A M Costello; E O Reynolds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  30     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  457-71     Citation Subset:  IM    
Department of Paediatrics, University College London.
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MeSH Terms
Brain / pathology
Brain Damage, Chronic / pathology
Cerebral Hemorrhage / pathology*
Cerebral Ventricles / pathology
Diagnosis, Differential
Germ Layers / pathology
Hydrocephalus / pathology
Hypoxia, Brain / pathology*
Infant, Newborn
Infant, Premature, Diseases / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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