Document Detail


Precision editing of large animal genomes.
MedLine Citation:
PMID:  23084873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.
Authors:
Wenfang Spring Tan; Daniel F Carlson; Mark W Walton; Scott C Fahrenkrug; Perry B Hackett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Advances in genetics     Volume:  80     ISSN:  0065-2660     ISO Abbreviation:  Adv. Genet.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-01-21     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0370421     Medline TA:  Adv Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Domestic / genetics
Animals, Genetically Modified
Disease Models, Animal*
Food Supply
Genetic Engineering* / legislation & jurisprudence,  methods
Genome
Humans
Meat*
Grant Support
ID/Acronym/Agency:
1R01DK082516/DK/NIDDK NIH HHS; 1R41HL108440/HL/NHLBI NIH HHS; 1R43 RR033149/RR/NCRR NIH HHS; P01 HD032652/HD/NICHD NIH HHS; P01HD32652/HD/NICHD NIH HHS; R01 DK082516/DK/NIDDK NIH HHS
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