| Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories. | |
| | |
MedLine Citation:
|
PMID: 14635149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals. MATERIALS AND METHODS: CASL perfusion MRI measurements of CBF on a 1.5-T GE Signa magnet were repeated in young healthy male and female subjects at one hour and one week. Precision of the measurement was evaluated at both time intervals. RESULTS: CASL perfusion MRI measurements of CBF yielded within-subject coefficients of variation (wsCV) of 5.8% for global and 13% for individual vascular regions when measurements were repeated within one hour. Differences in these values represent the error in post-processing. Global and regional CBF measurements over one week yielded wsCVs of 13% and 14%, respectively. At one week, error secondary to physiologic variability affected global and regional measurements to the same degree and masked the software post-processing error seen at one hour. The magnitude of the difference in repeated measures correlated with the magnitude of the measurement. CONCLUSION: CASL perfusion MRI CBF measurements are accurate and precise. Variability over longer periods of time appears attributable to physiologic factors. Repeatability of the CASL measurement is sensitive to the magnitude of the measurement. This should be taken into account when studies requiring repeated measures involve subjects with significant variability in CBF. |
| | |
Authors:
|
Thomas F Floyd; Sarah J Ratcliffe; Jiongjiong Wang; Brooke Resch; John A Detre |
Related Documents
:
|
18034339 - Immediate ct findings following embolization of cerebral aneurysms: suggestion of blood... 6981659 - Tomographic study of regional cerebral blood flow in ischemic cerebrovascular disease b... 8351629 - Resolution of focal ct hypodense lesions in patients with subarachnoid hemorrhage. 9226309 - Large intracranial vessel occlusive vasculopathy after radiation therapy in children: c... 13679259 - Short-term changes in cerebral microhemodynamics after carotid stenting. 16075409 - Comparison of perfusion mri by flow-sensitive alternating inversion recovery and dynami... 15544479 - Contribution of conformationally constrained calcitonin (ct) analogs to the understandi... 18528189 - Technical note: identifying the prostate cancer 'superscan' by quantitative skeletal sc... 897159 - Attenuation values in computed tomography of the abdomen. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 18 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2003 Dec |
Date Detail:
|
Created Date: 2003-11-24 Completed Date: 2004-03-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 649-55 Citation Subset: IM |
Copyright Information:
|
Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
|
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. floydt@uphs.upenn.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Brain / blood supply*, physiology* Cerebrovascular Circulation / physiology Female Humans Magnetic Resonance Angiography / methods* Male Regional Blood Flow / physiology Sensitivity and Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
HD39621/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DTI-based three-dimensional tractography detects differences in the pyramidal tracts of infants and ...
Next Document: Multislice T1 relaxation time measurements in the brain using IR-EPI: reproducibility, normal values...