| Precise histological evaluation of liver biopsy specimen is indispensable for diagnosis and treatment of acute-onset autoimmune hepatitis. | |
| | |
MedLine Citation:
|
PMID: 19107339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The diagnosis of acute-onset autoimmune hepatitis (AIH) has been difficult because patients do not always show clinicopathological features typical of AIH. We examined the important requirements for a definitive diagnosis of acute-onset AIH. METHODS: Clinical, biochemical, and pathological features of 18 acute-onset AIH patients (16 women, 2 men; mean age, 54.3 +/- 12.3 years) with no history of liver disease and no signs of chronicity were examined. RESULTS: Mean ALT was 679 +/- 431 IU/l, and mean T-Bil was 2.4 +/- 2.9 mg/dl. Mean IgG was 1801 +/- 446 mg/dl, with 7 patients (39%) showing normal levels. Antinuclear antibody was <or=1: 40 in 7 (39%). Liver histology showed severe activity in 17 (94%) of the patients and severe acute hepatitis in 7 (39%). Centrizonal necrosis and plasma cell accumulation were characteristic for acute-onset AIH. AIH score ranged from 7 to 18 (13.2 +/- 3.8) before treatment. All patients were diagnosed and treated early and responded completely to therapy. CONCLUSIONS: Histological examination of the liver is necessary for early diagnosis of acute-onset AIH. Moreover, we should evaluate liver biopsy specimens precisely and should be ready for a timely initiation of corticosteroid therapy to improve the prognosis. |
| | |
Authors:
|
Keiichi Fujiwara; Yoshihiro Fukuda; Osamu Yokosuka |
Related Documents
:
|
8918759 - Treatment of chronic hepatitis c: another therapeutic option. 424969 - Amoebic liver abscess in patients presenting with jaundice. a report of 5 cases. 15492609 - Prevalence and natural history of gastric antral vascular ectasia in patients undergoin... 1782729 - Heterogeneity of patients with late onset ornithine transcarbamylase deficiency. 1607609 - Can nsaids cause acute biliary pain with cholestasis? 3998769 - Functional and morphometric study of the liver in motor neuron disease. 9867039 - Blunt vascular injuries of the head and neck: is heparinization necessary? 16372619 - Secondary abdominal compartment syndrome: risk factors and outcomes. 9754899 - Venous ulcers in chronic venous insufficiency: king khalid university hospital experience. |
Publication Detail:
|
Type: Journal Article Date: 2008-12-24 |
Journal Detail:
|
Title: Journal of gastroenterology Volume: 43 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-12-24 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
|
Languages: eng Pagination: 951-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Alanine Transaminase Antibodies, Antinuclear / blood Bilirubin / blood Biopsy, Needle / methods* Female Hepatitis, Autoimmune / diagnosis*, drug therapy, pathology Humans Immunoglobulin G / blood Liver / pathology* Liver Function Tests Male Middle Aged Necrosis / diagnosis Prognosis |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antinuclear; 0/Immunoglobulin G; 635-65-4/Bilirubin; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hep...
Next Document: Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma.