| Precise control of end-tidal carbon dioxide and oxygen improves BOLD and ASL cerebrovascular reactivity measures. | |
| | |
MedLine Citation:
|
PMID: 20648687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In-depth investigation of cerebrovascular blood flow and MR mechanisms underlying the blood oxygenation level dependent signal requires precise manipulation of the arterial partial pressure of carbon dioxide and oxygen, measured by their noninvasive surrogates, the end-tidal values. The traditional methodology consists of administering a fixed fractional concentration of inspired CO(2), but this causes a variable ventilatory response across subjects, resulting in different values of end-tidal partial pressures of CO(2) and O(2). In this study, we investigated whether fine control of these end-tidal partial pressures would improve stability and predictability of blood oxygenation level dependent and arterial spin labeling signals for studying cerebrovascular reactivity. In 11 healthy volunteers, we compared the MR signals generated by the traditional fixed fractional concentration of inspired CO(2) method to those of an automated feed-forward system, a simpler, safer, and more compact alternative to dynamic end-tidal forcing systems, designed to target constant end-tidal partial pressures of CO(2) and O(2). We found that near square-wave changes in end-tidal partial pressure of CO(2) of 5, 7.5, and 10 mm Hg (+/-1.01 mm Hg within two to three breaths) and constrained changes in the end-tidal partial pressure of O(2) (<10 mm Hg) induced cerebral vascular reactivity measurements with faster transitions, together with improved stability and gradation, than those achieved with the traditional fixed fractional concentration of inspired CO(2) method. |
| | |
Authors:
|
Clarisse I Mark; Marat Slessarev; Shoji Ito; Jay Han; Joseph A Fisher; G Bruce Pike |
Related Documents
:
|
16223767 - Control of arterial pco2 by somatic afferents in sheep. 14995277 - Renormalized random walk study of oxygen absorption in the human lung. 7784757 - The relationship of hypercapnic ventilatory responses to age, gender and athleticism. 17901037 - The effects of co2 pneumoperitoneum on the apoptotic index in the peritoneum. 18638097 - Decreased hemodialysis circuit pressures indicating postpump tubing kinks: a retrospect... 6807 - Perinephritis hypertension in monkeys. i. an increase of plasma renin activity associat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-31 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 749-56 Citation Subset: IM |
Copyright Information:
|
2010 Wiley-Liss, Inc. |
Affiliation:
|
McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada. clarisse.mark@mail.mcgill.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbon Dioxide
/
blood* Cerebrovascular Circulation / physiology* Equipment Design Equipment Failure Analysis Female Humans Image Enhancement / methods* Magnetic Resonance Angiography / instrumentation*, methods Male Oxygen / blood* Pulmonary Gas Exchange / physiology* Respiration, Artificial / instrumentation* Tidal Volume / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development and validation of GC/MS method for determination of pramipexole in rat plasma.
Next Document: Removal of CSF pixels on brain MR perfusion images using first several images and Otsu's thresholdin...