Document Detail


Prebreeding maternal immunostimulation with Freund's complete adjuvant reduces placental damage and distal limb defects caused by methylnitrosourea.
MedLine Citation:
PMID:  16433834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Immunostimulation reduces murine teratogen-induced birth defects. It is unclear if placental improvement contributes to this outcome. The current study examined murine placental ultrastructure and fetal limb development following maternal methylnitrosourea (MNU) exposure, +/-Freund's complete adjuvant (FCA) immunostimulation. METHOD OF STUDY: Two murine strains (CD-1, C57BL/6N) were administered MNU on gestation day 9 (GD9), FCA pre-breeding, or FCA + MNU. Fetal limb and placental development were examined on GD14. RESULTS: MNU decreased placental weight and reduced placental cellular viability; FCA reversed these effects. MNU shortened fetal limbs and increased digital defects in both strains. Placentas were less damaged in C57BL/6N versus CD-1 mice, and distal limb malformations improved only in CD-1 mice. FCA immunostimulation also increased pregnancy rate. CONCLUSION: Improved fetal outcome from immune-stimulated mice may not be dependent on improved placental morphology. However, placental function and morphology in immune-stimulated mice may not directly correlate, thus functional improvements should be examined for possible relationship to reduced birth defects.
Authors:
Mary Renee Prater; Kurt L Zimmerman; Chelsea L Laudermilch; Steven D Holladay
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  55     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-25     Completed Date:  2006-05-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  145-55     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA 24060, USA. mrprater@vt.edu
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / embryology,  immunology,  prevention & control*
Animals
Female
Fetal Weight / drug effects
Freund's Adjuvant / therapeutic use*
Limb Deformities, Congenital / chemically induced,  immunology,  prevention & control*
Male
Maternal-Fetal Exchange
Methylnitrosourea / toxicity*
Mice
Mice, Inbred C57BL
Placenta / chemistry,  drug effects*,  pathology
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Grant Support
ID/Acronym/Agency:
1-K01-RR-17018/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
684-93-5/Methylnitrosourea; 9007-81-2/Freund's Adjuvant

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