| Prebreeding maternal immunostimulation with Freund's complete adjuvant reduces placental damage and distal limb defects caused by methylnitrosourea. | |
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MedLine Citation:
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PMID: 16433834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: Immunostimulation reduces murine teratogen-induced birth defects. It is unclear if placental improvement contributes to this outcome. The current study examined murine placental ultrastructure and fetal limb development following maternal methylnitrosourea (MNU) exposure, +/-Freund's complete adjuvant (FCA) immunostimulation. METHOD OF STUDY: Two murine strains (CD-1, C57BL/6N) were administered MNU on gestation day 9 (GD9), FCA pre-breeding, or FCA + MNU. Fetal limb and placental development were examined on GD14. RESULTS: MNU decreased placental weight and reduced placental cellular viability; FCA reversed these effects. MNU shortened fetal limbs and increased digital defects in both strains. Placentas were less damaged in C57BL/6N versus CD-1 mice, and distal limb malformations improved only in CD-1 mice. FCA immunostimulation also increased pregnancy rate. CONCLUSION: Improved fetal outcome from immune-stimulated mice may not be dependent on improved placental morphology. However, placental function and morphology in immune-stimulated mice may not directly correlate, thus functional improvements should be examined for possible relationship to reduced birth defects. |
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Authors:
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Mary Renee Prater; Kurt L Zimmerman; Chelsea L Laudermilch; Steven D Holladay |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 55 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-25 Completed Date: 2006-05-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 145-55 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA 24060, USA. mrprater@vt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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embryology,
immunology,
prevention & control* Animals Female Fetal Weight / drug effects Freund's Adjuvant / therapeutic use* Limb Deformities, Congenital / chemically induced, immunology, prevention & control* Male Maternal-Fetal Exchange Methylnitrosourea / toxicity* Mice Mice, Inbred C57BL Placenta / chemistry, drug effects*, pathology Pregnancy Pregnancy Outcome Pregnancy Rate |
| Grant Support | |
ID/Acronym/Agency:
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1-K01-RR-17018/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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684-93-5/Methylnitrosourea; 9007-81-2/Freund's Adjuvant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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