| Prebiotic treatment of experimental colitis with germinated barley foodstuff: a comparison with probiotic or antibiotic treatment. | |
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MedLine Citation:
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PMID: 11744999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is increasing evidence that intestinal microflora play an important role in the pathogenesis of ulcerative colitis. Therefore, modification of the microflora by prebiotics, probiotics, and antibiotics may be a rational approach for controlling intestinal inflammation. Germinated barley food-stuff (GBF) is an insoluble mixture of glutamine-rich protein and hemicellulose-rich dietary fiber. GBF is utilized efficiently by Bifidobacterium, Lactobacillus, and Eubacterium and converted by them into lactate, acetate, and butyrate. These bacterial organic acids preserve a favorable intestinal condition. We have previously shown that GBF has attenuated intestinal inflammation in patients with ulcerative colitis and experimental colitis models through prebiotic actions. The aim of this study was to compare the effect of GBF with that of probiotics and antibiotics in an experimental colitis model. Colitis was induced by feeding male SD rats with a diet containing 3.0-3.5% dextran sodium sulfate (DSS). The therapeutic effect of oral administration of a prebiotic (GBF), probiotics (mixture of Lactobacillus and Clostridium butyricum), antibiotics (vancomycin, metronidazole), and the vehicle was determined by assessing clinical and pathological scores on day 6 after initiation of colitis. Butyrate concentrations in the cecal content were also determined. GBF treatment significantly reduced colonic inflammation as assessed by clinical scores with an increase in cecal butyrate levels. Probiotic treatment with a mixture of Lactobacillus and Clostridium butyricum did not show such an effect. Both antibiotic treatments significantly attenuated clinical and pathological scores. However, in contrast to GBF, this treatment led to a significant decrease in cecal butyrate levels. These data suggest that modification of the intestinal microflora by prebiotics, including GBF, may serve as a useful adjunct in the treatment of ulcerative colitis as well as antibiotic treatment. |
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Authors:
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Masanobu Fukuda; Osamu Kanauchi; Yoshio Araki; Akira Andoh; Keiichi Mitsuyama; Kohsuke Takagi; Atsushi Toyonaga; Michio Sata; Yoshihide Fujiyama; Masamichi Fukuoka; Yoshiaki Matsumoto; Tadao Bamba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of molecular medicine Volume: 9 ISSN: 1107-3756 ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2001-12-17 Completed Date: 2002-03-07 Revised Date: 2006-04-13 |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Pharmaceutical Division, Kirin Brewery Co. Ltd., Shibuya-ku, Tokyo 150-8011, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Anti-Bacterial Agents / therapeutic use Anti-Infective Agents / therapeutic use Body Weight Colitis / diet therapy, drug therapy*, prevention & control Diet Disease Models, Animal Hordeum* Male Metronidazole / therapeutic use Phytotherapy* Plant Preparations / therapeutic use* Probiotics / therapeutic use Rats Rats, Sprague-Dawley Vancomycin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Plant Preparations; 1404-90-6/Vancomycin; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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