| Prebiotic synthesis of nucleotides. | |
| | |
MedLine Citation:
|
PMID: 11296526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
If an RNA-only world preceded more complex forms of life, then it is essential that the process whereby the first nucleotides were made be considered. Presumably there were no enzymes and no templates to facilitate the synthesis of the first nucleotides so another form of chemical evolution must have been involved. Answers to problems of this sort were sought vigorously in the 1960s and the early 1970s but many issues were left unresolved. Progress made in the last few years has added to this early work and brings us closer to a satisfactory solution. In this article key results, old and new, and some ideas as to how further progress is likely to be made are discussed. There are reasons for optimism. Substantial progress has been made on the synthesis of purines and ribose, phosphorylation and polyphosphorylation. The outstanding problems at this juncture relate to the synthesis of ribose to the exclusion of the other aldopentoses and to the problem of linking ribose to the purine bases. |
| | |
Authors:
|
G Zubay; T Mui |
Related Documents
:
|
6381226 - Acetylcoenzyme a and the synthesis of acetylcholine in neurones: review of recent progr... 21033196 - Kant and the scientific study of consciousness. 21239596 - Responding to partners' expression of anger: the role of communal motivation. 8972956 - Dental erosion as a consequence of voluntary regurgitation in a jockey: a case report. 4007716 - The diagnosis of diffuse axonal injury in routine autopsy practice. 22184216 - Collaborative learning in networks. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life Volume: 31 ISSN: 0169-6149 ISO Abbreviation: Orig Life Evol Biosph Publication Date: 2001 Feb-Apr |
Date Detail:
|
Created Date: 2001-04-11 Completed Date: 2001-07-12 Revised Date: 2001-11-13 |
Medline Journal Info:
|
Nlm Unique ID: 8610391 Medline TA: Orig Life Evol Biosph Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 87-102 Citation Subset: IM; S |
Affiliation:
|
Department of Biological Sciences, Columbia University, New York, NY 10027, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biogenesis Evolution, Chemical Lead / chemistry Nucleotides / chemical synthesis* Phosphorylation Purines / chemistry Ribose / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Nucleotides; 0/Purines; 50-69-1/Ribose; 7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The sugar model: catalysis by amines and amino acid products.
Next Document: Development of a physical performance scale for patients with implanted pacemakers